Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them

A sulfonimidamide of the formula I ##STR12## in which:

• at least one of the three substituents R(1 ), R(2) and R(3) is a benzoylguanidine ##STR13## which is unsubstituted or substituted in the phenyl moiety by 1-4 radicals selected from the group consisting of alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, --(CH.sub.2).sub.m --R(14), F, Cl, Br, I, --C.tbd.N, CF.sub.3, R(22)SO.sub.2 --, R(23)R(24)N--CO--, R(25)--CO--, R(26)R(27)N--SO.sub.2, --OR(35), --SR(35) or --NR(35)R(36);
• m is zero, 1 or 2;
• R(14) is --(C.sub.3 -C.sub.8)-cycloalkyl or phenyl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F and Cl, --CF.sub.3, methyl, methoxy and --NR(15)R(16);
• R(15) and R(16) independently of one another are hydrogen or --CH.sub.3 ;
• R(22), R(23), R(25) and R(26) independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, alkenyl having 2, 3, 4, 5, 6, 7 or 8 carbon atoms, (CH.sub.2).sub.n R(29) or --CF.sub.3 ;
• n is zero, 1, 2, 3 or 4;
• R(29) is --(C.sub.3 -C.sub.7)-cycloalkyl or phenyl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, --CF.sub.3, methyl, methoxy and --NR(30)R(31);
• R(30) and R(31) are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• or
• R(23), R(25) and R(26) are hydrogen;
• R(24) and R(27) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• or
• R(23) and R(24) and also R(26) and R(27) together are 5 or 6 methylene groups, of which a CH.sub.2 group can be replaced by oxygen, --S--, --NH--, --NCH.sub.3 or --N-benzyl;
• R(35) and R(36) independently of one another are hydrogen or alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms;
• or
• R(35) and R(36) together are 4-7 methylene groups, of which a CH.sub.2 group can be replaced by oxygen, --S--, --NH--, --NCH.sub.3 or --N-benzyl;
• or
• R(35) is phenyl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, --CF.sub.3, methyl, methoxy, SO.sub.2 R(5), SO.sub.2 NR(6)R(7) and --NR(32)R(33);
• R(5) is alkyl having 1, 2, 3, 4, 5 or 6 carbon atoms R(6) and R(7) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• R(32) and R(33) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• or
• R(35) is C.sub.1 -C.sub.9 -heteroaryl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF.sub.3, CH.sub.3, methoxy, hydroxyl, amino, methylamino and dimethylamino;
• and the other substituents R(1 ), R(2) and R(3) in each case independently of one another are alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, (CH.sub.2).sub.p R(10)
• p is zero, 1, 2, 3 or 4;
• R(10) is phenyl, which is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, --CF.sub.3, methyl, methoxy, --SO.sub.2 NR(17)R(8) and --SO.sub.2 R(9);
• R(17) and R(8) independently of one another are hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• R(9) is alkyl having 1, 2, 3 or 4 carbon atoms;
• or the other radical R(1 ) and R(3) in each case is hydrogen,
• R(4) is hydrogen or alkyl having 1, 2, 3 or 4 carbon atoms;
• or its pharmaceutically tolerable salts.