# US 5,708,029 A · High blood pressure relief method and compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,708,029 A - Document ID: US5708029A - Status: Granted - Kind: A - Application number: 08/559,758 - Filed: 1995-11-13 - Granted: 1998-01-13 - Earliest claimed: 1995-11-13 - Inventors: Arthur Vanmoor - Web page: https://patentgrep.com/patent/US5708029A ## CPC - A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) - A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract Disclosed is the method of determining the effectiveness of an agent for the relief of elevation of the blood pressure, comprising the steps of a) administering to a susceptible subject a quantity of a trigger substance reproducibly effective in producing within a period of six hours a perceptible increase in blood pressure lasting for at least twenty-four hours in the absence of treatment, b) administering to said subject having received said quantity of trigger substance a predetermined quantity of the agent whose effectiveness is to be determined, c) measuring the duration of said elevation of blood pressure upon administering said agent, and d) comparing the duration of said elevation with and without the administration of said agent. Also disclosed are effective quantities of certain nutrient substances which can reproducibly relieve elevated blood pressure produced in a susceptible subject by the administration of a trigger substance. ## Claims ### Claim 1 The method of determining the effectiveness of an agent for the relief of elevated blood pressure in a person comprising the steps of a) administering to a susceptible person a quantity of a trigger substance, which is a meat product or a product increasing body cholesterol levels, reproducibly effective in producing within a period of six hours a perceptible increase in blood pressure lasting for at least twenty-four hours in the absence of treatment, b) administering to said person receiving said quantity of trigger substance a predetermined quantity of the agent whose effectiveness is to be determined, c) measuring the duration of said elevation of blood pressure upon administering said agent, and d) comparing the duration of said elevation with and without the administration of said agent, an effective agent being one that reduces to three hours maximum the duration of said elevation of blood pressure before returning to normal level. ### Claim 2 (depends on 1) The method of claim 1 in which said trigger substance and said agent are administered simultaneously. ### Claim 3 (depends on 1) The method of claim 1 in which said agent is administered between one minute and three hours after the administration of said trigger substance. ### Claim 4 (depends on 1) The method of claim 1 in which said agent is administered prior to the administration of said trigger substance. ### Claim 5 (depends on 1) The method of claim 1 in which the quantity of trigger substance is in the range from 50 grams to 500 grams. ### Claim 6 The method of relieving elevation of the blood pressure in a person in need of such relief, comprising the administration to such person of a quantity of an agent which is at least one nutrient compound having the formula ##STR10## in which X is selected from the group consisting of --CONH.sub.2, --NH.sub.2, and ##STR11## n is zero, one, two, or three, and p being one and q being zero, and --N(CH.sub.3).sub.3+, p being zero and q being one. ### Claim 7 (depends on 6) The method of claim 6 in which X is --CONH.sub.2 and n is one. ### Claim 8 (depends on 6) The method of claim 6 in which X is --NH.sub.2 and n is two. ### Claim 9 (depends on 6) The method of claim 6 in which X is --NH.sub.2 and n is three. ### Claim 10 (depends on 6) The method of claim 6 in which X is --N(CH.sub.3).sub.3+, n is zero, p is zero, and q is one. ### Claim 11 (depends on 6) The method of claim 6 in which X is ##STR12## and n is one. ### Claim 12 A palatable oral dosage form for relieving elevation of the blood pressure in a person in need of such relief comprising a carrier and a quantity of an agent which is at least one nutrient compound having the formula ##STR13## in which X is selected from the group consisting of --CONH.sub.2, ##STR14## n is zero, one, two, or three, and p being one and q being zero, and --N(CH.sub.3).sub.3+, p being zero and q being one. ### Claim 13 (depends on 12) A palatable oral dosage form according to claim 12 in which the agent comprises a compound in which X is --N(CH.sub.3).sub.3+, n is zero, p is zero, and q is one. ### Claim 14 (depends on 12) A palatable oral dosage form according to claim 12 in which the agent comprises a compound in which X is --CONH.sub.2 and n is one. ### Claim 15 (depends on 12) A palatable oral dosage form according to claim 12 in which the agent comprises a compound in which X is --NH.sub.2 and n is two or three. ### Claim 16 (depends on 12) A palatable oral dosage form according to claim 12 in which the agent comprises a compound in which X is ##STR15## and n is one. ### Claim 17 (depends on 12) A palatable oral dosage form according to claim 12 selected from the group consisting of a tablet, a gelatin capsule, a soup, and a fruit flavored drink. ### Claim 18 (depends on 12) A palatable oral dosage form according to claim 12 in which the proportions of carrier to agent are in the range of 4:1 to 1:4. ### Claim 19 (depends on 12) A palatable oral dosage form according to claim 12, in which the carrier is at least one naturally occurring carbohydrate. ### Claim 20 (depends on 19) A palatable oral dosage form according to claim 19, in which the carrier comprises lactose, sucrose, fructose, starch, or cellulose. ### Claim 21 (depends on 12) A palatable oral dosage form according to claim 12, in which the carrier comprises at least one ingestible mineral substance. ### Claim 22 (depends on 21) A palatable oral dosage form according to claim 21, in which the carrier comprises an alkaline earth metal carbonate or alkaline earth metal silicate. ### Claim 23 (depends on 12) A palatable oral dosage form according to claim 12, in which the carrier comprises at least one lipid. ### Claim 24 (depends on 23) A palatable oral dosage form according to claim 23, in which the carrier comprises lecithin or a fatty oil. ### Claim 25 (depends on 12) A palatable oral dosage form according to claim 12 in which the quantity of agent is in the range of 200 to 20000 milligrams. ### Claim 26 (depends on 12) A pleasant tasting oral dosage form according to claim 12, comprising an added flavorant. ### Claim 27 (depends on 26) A pleasant tasting oral dosage form according to claim 26, in which the flavorant is selected from the group consisting of herbs, spices, and essential oils. ### Claim 28 A pleasant tasting oral dosage form for relieving elevation of the blood pressure in a person in need of such relief comprising a carrier, at least one first nutrient compound having the formula ##STR16## in which X is --NH.sub.2, n is two or three, p is one and q is zero, and at least one second nutrient compound having the formula ##STR17## in which X is selected from the group consisting of --CONH.sub.2, and ##STR18## n is zero or one, and p being one and q being zero and --N(CH.sub.3).sub.3+, p being zero and q being one. ### Claim 29 (depends on 28) The composition of claim 28 in which the proportions of first nutrient compound and second nutrient compound are in the range from 4:1 to 1:4.