# US 5,708,023 A · Zinc gluconate gel compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,708,023 A - Document ID: US5708023A - Status: Granted - Kind: A - Application number: 08/492,080 - Filed: 1995-06-28 - Granted: 1998-01-13 - Earliest claimed: 1994-03-28 - Assignees: The Trustees of Columbia University in the City of New York - Inventors: Shanta M. Modak; Lester A. Sampath; Balram H. Advani - Web page: https://patentgrep.com/patent/US5708023A ## CPC - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A01N 25/32: Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions - A01N 47/44: Guanidine; Derivatives thereof - A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid - A61K 33/30: Zinc; Compounds thereof - A61K 33/38: Silver; Compounds thereof - A61P 13/02: of urine or of the urinary tract, e.g. urine acidifiers - A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives - A61P 31/02: Local antiseptics - A61P 31/04: Antibacterial agents - A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A composition of matter containing zinc gluconate gel as an irritant-inactivating agent, and a substance which substantially prevents the irritant-inactivating agent from binding to the surface, wherein the irritant-inactivating agent in the composition is present in an amount effective to inactivate irritants in fluids which contact the composition, is described. Surgical instruments and physical barriers with the aforementioned composition applied thereto are also described. A method of inactivating irritants in a fluid contacting skin comprising applying the aforementioned composition to the skin is also disclosed. A method of inactivating irritants in a fluid contacting skin covered with a physical barrier comprising applying the aforementioned composition to the skin is also disclosed. ## Claims ### Claim 1 A composition comprising a gel matrix formed from zinc gluconate and a solvent selected from the group consisting of water, alcohol, and combinations thereof, wherein the zinc gluconate acts as the sole gelling agent. ### Claim 2 (depends on 1) The composition of claim 1, wherein the gel matrix comprises 50% zinc gluconate. ### Claim 3 (depends on 1) The composition of claim 1 which comprises at least 10% zinc gluconate. ### Claim 4 (depends on 2) The composition of claim 2 which comprises at least 10% zinc gluconate. ### Claim 5 (depends on 1) The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 6 (depends on 1) The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alkylphenol compound. ### Claim 7 (depends on 1) The composition of claim 1 wherein the gel matrix comprises a therapeutically effective amount of an anti-allergen. ### Claim 8 (depends on 3) The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 9 (depends on 3) The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alklylphenol compound. ### Claim 10 (depends on 3) The composition of claim 3 wherein the gel matrix comprises a therapeutically effective amount of an anti-allergen. ### Claim 11 (depends on 4) The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 12 (depends on 4) The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of an antimicrobial agent selected from the group consisting of parachlorometaxylenol, triclosan, povidone iodine, benzalkonium chloride, a silver salt, and a polyoxyethylene alkylphenol compound. ### Claim 13 (depends on 4) The composition of claim 4 wherein the gel matrix comprises a therapeutically effective amount of anti-allergen. ### Claim 14 (depends on 5) The composition of claim 5 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 15 (depends on 14) The composition of claim 14 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 16 (depends on 8) The composition of claim 8 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 17 (depends on 16) The composition of claim 16 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 18 (depends on 11) The composition of claim 11 which comprises between about 0.5% to 10% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 19 (depends on 18) The composition of claim 18 which comprises between about 0.5% to 5% chlorhexidine or a pharmaceutically acceptable chlorhexidine salt. ### Claim 20 (depends on 1) The composition of claim 1 which is a topical antimicrobial cream. ### Claim 21 (depends on 5) The composition of claim 5 which is a topical antimicrobial cream. ### Claim 22 (depends on 6) The composition of claim 6 which is a topical antimicrobial cream. ### Claim 23 (depends on 7) The composition of claim 7 which is a topical antimicrobial cream. ### Claim 24 (depends on 1) The composition of claim 1 which is a vaginal cream. ### Claim 25 (depends on 5) The composition of claim 5 which is a vaginal cream. ### Claim 26 (depends on 6) The composition of claim 6 which is a vaginal cream. ### Claim 27 (depends on 7) The composition of claim 7 which is a vaginal cream. ### Claim 28 (depends on 1) The composition of claim 1 which is applicable to a wound dressing. ### Claim 29 (depends on 5) The composition of claim 5 which is applicable to a wound dressing. ### Claim 30 (depends on 6) The composition of claim 6 which is applicable to a wound dressing. ### Claim 31 (depends on 7) The composition of claim 7 which is applicable to a wound dressing. ### Claim 32 (depends on 1) The composition of claim 1 which is applicable to a surgical instrument. ### Claim 33 (depends on 5) The composition of claim 5 which is applicable to a surgical instrument. ### Claim 34 (depends on 6) The composition of claim 6 which is applicable to a surgical instrument. ### Claim 35 (depends on 7) The composition of claim 7 which is applicable to a surgical instrument. ### Claim 36 (depends on 1) The composition of claim 1 which is applicable to a glove. ### Claim 37 (depends on 5) The composition of claim 5 which is applicable to a glove. ### Claim 38 (depends on 6) The composition of claim 6 which is applicable to a glove. ### Claim 39 (depends on 7) The composition of claim 7 which is applicable to a glove. ### Claim 40 (depends on 1) The composition of claim 1 which is applicable to a condom. ### Claim 41 (depends on 5) The composition of claim 5 which is applicable to a condom. ### Claim 42 (depends on 6) The composition of claim 6 which is applicable to a condom. ### Claim 43 (depends on 7) The composition of claim 7 which is applicable to a condom. ### Claim 44 A method of preventing skin irritation comprising applying, to the skin, a composition comprising a gel matrix formed from zinc gluconate and a solvent selected from the group consisting of water, alcohol, and combinations thereof, wherein the zinc gluconate acts as the sole gelling agent.