# US 5,708,017 A · Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors

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- Number: US 5,708,017 A
- Document ID: US5708017A
- Status: Granted
- Kind: A
- Application number: 08/416,275
- Filed: 1995-04-04
- Granted: 1998-01-13
- Earliest claimed: 1995-04-04
- Assignees: Merck & Co., Inc.
- Inventors: Kaushik J. Dave; James B. Williams
- Web page: https://patentgrep.com/patent/US5708017A

## CPC

- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays}
- A61K 31/415: 1,2-Diazoles
- A61K 31/4184: condensed with carbocyclic rings, e.g. benzimidazoles
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is concerned with an oral pharmaceutical formulation containing a proton pump inhibitor (PPI) which is suitable for the treatment of gastric acid related diseases in man and animals. More specifically, the composition is a paste, and is particularly suitable for delivery of a proton pump inhibitor to horses.

## Claims

### Claim 1

A stable, ready-to-use pharmaceutical paste composition for oral administration which comprises: a proton pump inhibitor, a thickening agent, a basifying agent, and a hydrophobic oily liquid vehicle.

### Claim 2 (depends on 1)

A composition of claim 1 wherein said proton pump inhibitor is omeprazole.

### Claim 3 (depends on 1)

A composition of claim 1 wherein said thickening agent is hydrogenated castor oil.

### Claim 4 (depends on 1)

A composition of claim 1 wherein said hydrophobic liquid vehicle is capric/caprylic triglyceride.

### Claim 5 (depends on 2)

A composition of claim 2 wherein said basifying agent is potassium sorbate.

### Claim 6 (depends on 1)

A composition of claim 1 wherein said proton pump inhibitor is about 1 to about 35% by weight, and the thickening agent is about 2 to about 9% by weight.

### Claim 7 (depends on 6)

A composition of claim 6 wherein said proton pump inhibitor is omeprazole, said thickening agent is hydrogenated castor oil, and the hydrophobic liquid vehicle is capric/caprylic triglyceride.

### Claim 8 (depends on 1)

A composition of claim 1 wherein said proton pump inhibitor is omeprazole, said thickening agent is hydrogenated castor oil, said hydrophobic oil is capric/caprylic triglyceride, and said basifying agent is potassium sorbate.