# US 5,707,993 A · Glycine anhydride dimethylol as a biocide and preservative

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- Number: US 5,707,993 A
- Document ID: US5707993A
- Status: Granted
- Kind: A
- Application number: 08/058,238
- Filed: 1993-05-10
- Granted: 1998-01-13
- Earliest claimed: 1991-05-01
- Assignees: ISP Chemicals Inc.
- Inventors: Philip A. Berke; William E. Rosen
- Web page: https://patentgrep.com/patent/US5707993A

## CPC

- A61K 8/494: {with more than one nitrogen as the only hetero atom}
- A01N 43/60: 1,4-Diazines; Hydrogenated 1,4-diazines
- A23B 2/771: Organic compounds containing hetero rings
- A61K 31/495: having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53})
- A61P 31/04: Antibacterial agents
- A61Q 17/005: {Antimicrobial preparations}
- C02F 1/50: by addition or application of a germicide or by oligodynamic treatment {(C02F1/4606, C02F1/467, C02F1/76 take precedence)}
- A61K 2800/524: Preservatives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C02F: TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE (separation in general B01D; special arrangements on waterborne vessels of installations for treating water, waste water or sewage, e.g. for producing fresh water, B63J; adding materials to water to prevent corrosion C23F; treating radioactively-contaminated liquids G21F9/04; regeneration of reactants for recirculation into processes, see the relevant places for the processes)

## Abstract

The use of glycine anhydride dimethylol, also known as 1,4-bis(hydroxymethyl)-2,5-piperazinedione, comprising the formula ##STR1## to kill microorganisms present in or on a host substance and to preserve products susceptible to contamination by a variety of microorganisms is disclosed.

## Claims

### Claim 1

A method of killing microorganisms in or on a host substance comprising administering to the substance an effective biocidal amount of glycine anhydride dimethylol of the formula: ##STR4##

### Claim 2 (depends on 1)

The method as defined in claim 1, wherein the glycine anhydride dimethylol is administered in aqueous solution.

### Claim 3 (depends on 1)

The method as defined in claim 1, wherein the glycine anhydride dimethylol is administered in an emulsion.

### Claim 4 (depends on 1)

The method as defied in claim 1, wherein the glycine anhydride dimethylol is administered as a powder.

### Claim 5 (depends on 1)

The method as defined by claim 1, wherein the glycine anhydride dimethylol is administered in conjunction with another biocidal agent.