# US 5,707,986 A · Angiographic method using green porphyrins in primate eyes

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- Number: US 5,707,986 A
- Document ID: US5707986A
- Status: Granted
- Kind: A
- Application number: 08/209,473
- Filed: 1994-03-14
- Granted: 1998-01-13
- Earliest claimed: 1994-03-14
- Inventors: Joan W. Miller; Lucy H.Y. Young; Evangelos S. Gragoudas
- Web page: https://patentgrep.com/patent/US5707986A

## CPC

- A61K 9/1275: Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 31/409: having four such rings, e.g. porphine derivatives, bilirubin, biliverdine (hemin, hematin A61K31/555)
- A61K 31/555: containing heavy metals, e.g. hemin, hematin, melarsoprol
- A61K 41/0071: {PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines}
- A61K 49/0036: {Porphyrins (used in photodynamic therapy A61K41/0071 or A61K41/0076; used as targeting group or modifying agent for targeting a therapeutic compound A61K47/546)}
- A61K 49/0084: {liposome, i.e. bilayered vesicular structure}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

An angiographic method to observe the condition of blood vessels, including neovasculature in the eyes of living primates using green porphyrins and light at a wavelength of 550-700 nm to effect fluorescence is disclosed.

## Claims

### Claim 1

An angiographic method to observe the condition of blood vessels, including neovasculature in the eye of an intact living primate, which method comprises:
a. administering to said primate comprising at least one eye for which said observation is desired and containing said neovasculature an amount of green porphyrin which will provide an observable amount of green porphyrin in the blood vessels and neovasculature of said eye;
b. permitting sufficient time to elapse so that an observable amount of said green porphyrin resides in the blood vessels and neovasculature of the eye; and
c. applying light of a wavelength in the range of about 550-700 nm to the eye so as to effect fluorescence of the green porphyrin; and
d. detecting said fluorescence with a suitable camera.

### Claim 2 (depends on 1)

The method of claim 1 wherein said green porphyrin is a BPD.

### Claim 3 (depends on 2)

The method of claim 2 wherein said BPD is BPD-MA.

### Claim 4 (depends on 1)

The method of claim 1 wherein said green porphyrin is complexed with low-density lipoprotein.

### Claim 5 (depends on 1)

The method of claim 1 wherein said green porphyrin is contained in a liposomal preparation.

### Claim 6 (depends on 3)

The method of claim 3 wherein said BPD-MA is contained in a liposomal preparation.