# US 5,707,972 A · Hydrophilic polysaccharide-based pharmaceutical perparation for external use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,707,972 A - Document ID: US5707972A - Status: Granted - Kind: A - Application number: 08/610,965 - Filed: 1996-03-05 - Granted: 1998-01-13 - Earliest claimed: 1996-03-05 - Assignees: Shimizu Chemical Corporation - Inventors: Hideki Shimizu - Web page: https://patentgrep.com/patent/US5707972A ## CPC - A61K 31/736: Glucomannans or galactomannans, e.g. locust bean gum, guar gum - A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters - A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents - A61P 17/00: Drugs for dermatological disorders - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention provides a pharmaceutical preparation for the treatment of a wound consisting essentially of 200-mesh or finer powder of one or more hydrophilic polysaccharides selected from the group consisting of glucomannan and guar gum. Also provided is a pharmaceutical preparation for prophylaxis and treatment of chapped skin consisting essentially of an aqueous solution of one or more hydrophilic polysaccharides selected from the group consisting of glucomannan and guar gum. ## Claims ### Claim 1 A pharmaceutical preparation for external use consisting essentially of one or more powder form hydrophilic polysaccharides and one or more local anesthetics and/or antimicrobials. ### Claim 2 (depends on 1) The pharmaceutical preparation of claim 1 wherein the one ore more powder form hydrophilic polysaccharides are selected from the group consisting of glucomannan and guar gum. ### Claim 3 (depends on 2) The pharmaceutical preparation or claim 2 wherein the particle sizes of the powder form hydrophilic polysaccharides are substantially 200-mesh or smaller. ### Claim 4 (depends on 2) The pharmaceutical preparation of claim 2 wherein the one or more antimicrobials are selected from the group consisting of benzethonium chloride, benzalkonium chloride, chlorhexidine, chlorhexidine dihydrochloride, chlorhexidine diacetate and chlorhexidine gluconate. ### Claim 5 (depends on 1) The pharmaceutical preparation of claim 1 wherein the one or more local anesthetics are selected from the group consisting of dibucaine hydrochloride, tetracaine hydrochloride and lidocaine hydrochloride. ### Claim 6 A pharmaceutical preparation for external use consisting essentially of an aqueous solution of one or more hydrophilic polysaccharides and one or more preservatives and/or keratin softening preparations. ### Claim 7 (depends on 6) The pharmaceutical preparation of claim 6 wherein the one ore more hydrophilic polysaccharides are selected from the group consisting of glucomannan and guar gum. ### Claim 8 (depends on 7) The pharmaceutical preparation of claim 7 wherein the aqueous solution is obtainable by dissolving in water the one of more hydrophilic polysaccharides with substantial particle sizes of 200-mesh or smaller. ### Claim 9 (depends on 8) The pharmaceutical preparation of claim 8 wherein the total concentration of the one or more hydrophilic polysaccharides is 0.1 to 10.0 W/V %. ### Claim 10 (depends on 8) The pharmaceutical preparation of claim 8 wherein the one or more preservatives are selected from the group consisting of p-hydroxybenzoate derivatives, benzalkonium chloride, chlorhexidine, chlorhexidine dihydrochloride, chlorhexidine diacetate and chlorhexidine gluconate. ### Claim 11 (depends on 8) The pharmaceutical preparation of claim 8 wherein the keratin softening preparation is urea. ### Claim 12 A method of treatment of a skin wound of a human comprising spreading over the opening of the wound a therapeutically effective amount of a pharmaceutical preparation consisting essentially of one or more powder form hydrophilic polysaccharides selected from the group consisting of glucomannan and guar gum. ### Claim 13 (depends on 12) The method of claim 12 wherein the particle sizes of the one or more powder form hydrophilic polysaccharides are substantially 200-mesh or smaller. ### Claim 14 (depends on 12) The method of claim 12 wherein the pharmaceutical preparation contains one or more local anesthetics and/or antimicrobials. ### Claim 15 A method of prophylaxis and treatment of chapped skin of a human comprising applying to the skin area to be protected against or treated for chapping a prophylactically or therapeutically effective amount of a pharmaceutical preparation consisting essentially of an aqueous solution obtainable by dissolving in water one or more hydrophilic polysaccharides selected from the group consisting of glucomannan and guar gum at a total concentration of 0.1 to 10.0 W/V %. ### Claim 16 (depends on 15) The method of claim 15 wherein the preparation contains one or more preservatives and/or keratin softening preparations.