# US 5,707,967 A · Pain relief compositions

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,707,967 A
- Document ID: US5707967A
- Status: Granted
- Kind: A
- Application number: 08/549,649
- Filed: 1995-10-27
- Granted: 1998-01-13
- Earliest claimed: 1995-10-27
- Inventors: Arthur Vanmoor
- Web page: https://patentgrep.com/patent/US5707967A

## CPC

- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed are compositions containing either aspartame or monosodium glutanate combined with an amino acid.

## Claims

### Claim 1

A flavorant composition having a reduced tendency to produce a perceptible sensation of pain in a person susceptible to the pain-inducing tendency of monosodium glutamate, consisting essentially of monosodium glutamate and an agent which is at least one nutrient compound having the formula ##STR10## in which X is selected from the group consisting of ##STR11## n is zero, one, two, or three, and p and q are each zero or one, provided that p is zero and q is one only when X is --N(CH.sub.3).sub.3 +.

### Claim 2 (depends on 1)

The flavorant composition of claim 1 in which X is --SH and n is zero.

### Claim 3 (depends on 1)

The flavorant composition of claim 1 in which X is --CONH.sub.2 and n is one.

### Claim 4 (depends on 1)

The flavorant composition of claim 1 in which X is --SCH.sub.3 and n is one.

### Claim 5 (depends on 1)

The flavorant composition of claim 1 in which X is --NH.sub.2 and n is two or three.

### Claim 6 (depends on 1)

The flavorant composition of claim 1 in which X is ##STR12## and n is two.

### Claim 7 (depends on 1)

The flavorant composition of claim 1 in which X is ##STR13## and n is one.

### Claim 8 (depends on 1)

The flavorant composition of claim 1 in which X is --N(CH.sub.3).sub.3 +, n is zero, p is zero, and q is one.

### Claim 9 (depends on 1)

A flavorant composition according to claim 1, in which the relative proportions of monosodium glutamate to nutrient compound are in the range from 9:1 to 1:9.

### Claim 10

A sweetener composition having a reduced tendency to produce a perceptible sensation of headache in a person susceptible to the headache-inducing tendency of aspartame, consisting essentially of aspartame and an agent which is at least one nutrient compound having the formula ##STR14## in which X is selected from the group consisting of ##STR15## n is zero, one, two, or three, and p and q are each zero or one, provided that p is zero and q is one only when X is --N(CH.sub.3).sub.3 +.

### Claim 11 (depends on 10)

The sweetener composition of claim 10 in which X is --SH and n is zero.

### Claim 12 (depends on 10)

The sweetener composition of claim 10 in which X is --CONH.sub.2 and n is one.

### Claim 13 (depends on 10)

The sweetener composition of claim 10 in which X is --SCH.sub.3 and n is one.

### Claim 14 (depends on 10)

The sweetener composition of claim 10 in which X is --NH.sub.2 and n is two or three.

### Claim 15 (depends on 10)

The sweetener composition of claim 10 in which X is ##STR16## and n is two.

### Claim 16 (depends on 10)

The sweetener composition of claim 10 in which X is ##STR17## and n is one.

### Claim 17 (depends on 10)

The sweetener composition of claim 10 in which X is --N(CH.sub.3).sub.3 +, n is zero, p is zero, and q is one.

### Claim 18 (depends on 10)

A sweetener composition according to claim 10, in which the relative proportions of aspartame to nutrient compound are in the range from 9:1 to 1:9.