Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
AssigneeGenSci Regeneration Sciences Inc.
InventorsCharles C. Chen, Steven R. Jefferies
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Abstract
The present invention provides improved osteogenic compositions having enhanced by the sorption of growth factors, of nutrient factors, or drugs onto or into the compositions. Compositions may consist of collagen and demineralized bone materials onto and into which growth factors, antimicrobial agent, a nutrient factors, or other soluble factors may be sorbed to enhance the osteogenic factor. These materials can be used in a wide range of clinical procedures to replace and restore osseous or periodontal defects.
Claims15
A porous or semi-porous osteogenic composition comprising a porous or semiporous matrix of an organic or inorganic material and at least one osteogenic factor, wherein at least one agent selected from the group consisting of growth factors, nutrient factors, drugs, antimicrobial agents, calcium containing compounds, blood proteins or products, and anti-inflammatory agents is sorbed into or onto the porous or semi-porous matrix.
A method of making an osteogenic composition having enhanced osteogenic potential comprising:
- (a) forming a porous or semi-porous matrix of an inorganic or organic material and at least one osteogenic factor;
- and
- (b) sorbing at least one agent selected from the group consisting of growth factors, nutrient factors, drugs, antimicrobial agents, calcium containing compounds, blood proteins or products or anti-inflammatory agents into or onto said porous and semi-porous matrix.
Dependencies are inferred from the claim text.