# US 5,707,867 A · Antiviral compounds

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- Number: US 5,707,867 A
- Document ID: US5707867A
- Status: Granted
- Kind: A
- Application number: 08/565,085
- Filed: 1995-11-30
- Granted: 1998-01-13
- Earliest claimed: 1993-10-27
- Assignees: The Regents of the University of California
- Inventors: Jeffrey S. Glenn
- Web page: https://patentgrep.com/patent/US5707867A

## CPC

- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 31/436: the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61K 38/13: Cyclosporins
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The macrolide FK506, produced by Fujisawa Pharmaceuticals is effective in inhibiting the replication of hepatitis D virus. It is believed that replication is inhibited either by virtue of the ability of FK506 to inhibit proline isomerase or otherwise to interfere with the function of a C-terminal proline in a replication factor or by virtue of its interference with RNA replication directly.

## Claims

### Claim 1

A method to inhibit the replication of a virus that requires proline isomerase for replication, said method comprises the step of contacting a cell in which said virus replicates with an amount of a proline isomerase inhibitor sufficient to inhibit replication.

### Claim 2

A method to inhibit the replication of a virus that requires proline isomerase for replication, said method comprises the step of contacting a cell in which said virus replicates with an amount of a compound of the formula: ##STR2## or a pharmaceutically acceptable acyl (1-6C) ester thereof sufficient to inhibit replication.

### Claim 3

A method to inhibit the replication of a virus that requires proline isomerase for replication, said method comprises the step of contacting a cell in which said virus replicates with an mount of a compound selected from the group consisting of FK506 rapamycin and 506BD sufficient to inhibit replication.

### Claim 4

A method to inhibit the replication of hepatitis D virus, said method comprises the step of contacting a cell in which said virus replicates with an amount of a proline isomerase inhibitor sufficient to inhibit replication.

### Claim 5

A method to inhibit the replication of hepatitis D virus, said method comprises the step of contacting a cell in which said virus replicates with an amount of a compound of the formula sufficient to inhibit replication: ##STR3## or a pharmaceutically acceptable acyl (1-6C) ester thereof sufficient to inhibit replication.