# US 5,707,854 A · Lactic acid bacteria of the Genus lactobacillus

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- Number: US 5,707,854 A
- Document ID: US5707854A
- Status: Granted
- Kind: A
- Application number: 08/579,573
- Filed: 1995-12-27
- Granted: 1998-01-13
- Earliest claimed: 1994-03-11
- Assignees: The Calpis Food Industry Co., Ltd.
- Inventors: Yoshio Saito; Jun Mizutani
- Web page: https://patentgrep.com/patent/US5707854A

## CPC

- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- C12N 1/205: Bacterial isolates
- A61P 3/06: Antihyperlipidemics
- C12R 2001/225: Lactobacillus
- C12R 2001/23: Lactobacillus acidophilus
- Y10S 435/822: using bacteria or actinomycetales
- Y10S 435/854: Lactobacillus acidophilus
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Lactic acid bacteria of the genus Lactobacillus do not exhibit deconjugation of bile acids and inhibition of nutrient absorption, and exhibit lowering of cholesterol in blood and liver. The particular species of the genus Lactobacillus exhibiting these characteristics is Lactobacillus acidophilus. Furthermore, the strain Lactobacillus acidophilus CL-0062 has been internationally deposited under accession number FERM BP-4980.

## Claims

### Claim 1

A biologically pure culture of a Lactobacillus acidophilus bacterial strain wherein said Lactobacillus acidophilus bacterial strain does not deconjugate taurocholic or glycocholic acid, does not inhibit nutrient absorption, and lowers cholesterol levels in blood and liver of an animal when ingested by said animal.