# US 5,707,845 A · Organic electronic element from modified cytochrome c551 and cytochrome c552

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- Number: US 5,707,845 A
- Document ID: US5707845A
- Status: Granted
- Kind: A
- Application number: 08/544,608
- Filed: 1995-10-18
- Granted: 1998-01-13
- Earliest claimed: 1991-09-17
- Assignees: Mitsubishi Denki Kabushiki Kaisha
- Inventors: Satoshi Ueyama; Satoru Isoda; Ken-ichi Inatomi; Hiroaki Kawakubo
- Web page: https://patentgrep.com/patent/US5707845A

## CPC

- H10K 10/701: {Organic molecular electronic devices}
- B82Y 10/00: Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
- H01B 1/12: organic substances {(organic macromolecular compounds or compositions C08)}
- H10K 85/761: {Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes}
- H10K: ORGANIC ELECTRIC SOLID-STATE DEVICES
- B82Y: SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- H01B: CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES (selection for magnetic properties H01F1/00; waveguides H01P {; printed circuits H05K})

## Abstract

An organic electronic element material has been produced by modifying cytochrome c551 and cytochrome c552 by bonding at least a second electron transfer functional group to an amino acid residue of the cytochrome. The residue for attachment of the additional electron transfer groups could be introduced by genetic engineering or generated by chemical modification. A plurality of different electron transfer groups can be introduced to provide different redox potentials. Electron transfer can be caused to occur between the functional groups on the modified cytochromes to provide a desired electric property such as rectification, or switching in response to light.

## Claims

### Claim 1

An electronic element comprising:
an electrode and a monomolecular film, wherein
said film is absorbed to said electrode and comprises a modified protein,
said modified protein comprising a cytochrome which has a first electron transfer functional group having a first redox potential, wherein said cytochrome has been modified by covalently bonding a second electron transfer functional group which has a second redox potential to an amino acid residue of said cytochrome, selected from the group consisting of Lys 76 modified to Cys 76 and Trp 77 modified to Cys 77 said second electron transfer group being located so as to allow electron transfer between said first and second electron transfer functional groups, wherein said cytochrome is cytochrome c551, and
wherein said redox potential of said first electron transfer functional group is different from said redox potential of said second electron transfer functional group.

### Claim 2

An electronic element comprising:
an electrode and a monomolecular film, wherein
said film is absorbed to said electrode and comprises a modified protein,
said modified protein comprising a cytochrome which has a first electron transfer functional group having a first redox potential, wherein said cytochrome has been modified by covalently bonding a second electron transfer functional group which has a second redox potential to an amino acid residue of said cytochrome selected from the group consisting of Lys 70 modified to Cys 70 and Trp 75 modified to Cys 75, said second electron transfer group being located so as to allow electron transfer between said first and second electron transfer functional groups, wherein said cytochrome is cytochrome c552, and
wherein said redox potential of said first electron transfer functional group is different from said redox potential of said second electron transfer functional group.

### Claim 3 (depends on 1, 2)

An electronic element as in claims 1 or 2 wherein said first and second electron transfer functional groups are selected from the group consisting of heme and flavin.

### Claim 4 (depends on 1, 2)

An electron element as in claims 1 or 2 wherein said second electron transfer functional group is selected from the group consisting of metalloporphyrin, metallophthalocyanine, ferrocene, porphyrin, phthalocyanine, quinone, isoalloxazine, pyridine nucleotide, viologen, tetracyanoquinodimethane, a metal atom having electron transfer capability, a metal ion which transfers electrons and iron sulfur cluster.