# US 5,707,838 A · Antibiotic produced by Pseudomonas sp. and process for the preparation thereof

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- Number: US 5,707,838 A
- Document ID: US5707838A
- Status: Granted
- Kind: A
- Application number: 08/619,508
- Filed: 1996-03-28
- Granted: 1998-01-13
- Earliest claimed: 1994-08-05
- Assignees: Shionogi & Co., Ltd.
- Inventors: Reiji Takeda; Shigetada Hidaka; Shinobu Kobayashi; Yoshio Hayase; Mamoru Ozaki; Hiroshi Nakai
- Web page: https://patentgrep.com/patent/US5707838A

## CPC

- C12P 17/167: {Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs}
- C07D 277/12: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D 277/56: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The invention is a compound of the formula: ##STR1## wherein M is a bivalent or trivalent metal ion, and X is OH or O.sup..crclbar.. The above compound of the present invention is useful for prevention or treatment of mycoplasmosis.

## Claims

### Claim 1

A compound of the formula: ##STR7## wherein M is a bivalent or trivalent metal ion and X is OH or O.sup..crclbar..

### Claim 2 (depends on 1)

The compound of claim 1 of the formula: ##STR8## wherein M and X are as defined in claim 1.

### Claim 3 (depends on 2)

A compound of claim 2 wherein M is Zn.sup.2+, Cu.sup.2+, Fe.sup.2+, Fe.sup.3+, Co.sup.2+, Ni.sup.2+, Mn.sup.2+, Mn.sup.3+, Cd.sup.2+, Mg.sup.2+, Ca.sup.2+, Sr.sup.2+, Ba.sup.2+, V.sup.2+, V.sup.3+, Cr.sup.2+, Al.sup.3+, Sn.sup.2+, Pb.sup.2+ or Ag.sup.2+.

### Claim 4 (depends on 2)

A compound of claim 2 wherein M is Zn.sup.2+, Cu.sup.2+, Fe.sup.3+, Co.sup.2+ or Ni.sup.2+.

### Claim 5 (depends on 1)

The compound of claim 1 wherein M is Zn.sup.2+, Cu.sup.2+, Fe.sup.2+, Fe.sup.3+, Co.sup.2+, Ni.sup.2+, Mn.sup.2+, Mn.sup.3+, Cd.sup.2+, Mg.sup.2+, Ca.sup.2+, Sr.sup.2+, Ba.sup.2+, V.sup.2+, V.sup.3+, Cr.sup.2+, Al.sup.3+, Sn.sup.2+, Pb.sup.2+ or Ag.sup.2+.

### Claim 6 (depends on 1)

The compound of claim 1 wherein M is Zn.sup.2+, Cu.sup.2+, Fe.sup.3+, Co.sup.2 + or Ni.sup.2+.

### Claim 7 (depends on 1)

A pharmaceutical composition containing the compound of claim 1 in combination with one or more pharmaceutically acceptable carriers.

### Claim 8 (depends on 1)

A veterinary composition containing the compound of claim 1 in combination with one or more pharmaceutically acceptable carriers.

### Claim 9 (depends on 1)

An anti-mycoplasma agent containing the compound of claim 1 in combination with one or more pharmaceutically acceptable carriers.

### Claim 10

A process for preparing a compound of the formula: ##STR9## where M.degree. is Cu.sup.2+, Zn.sup.2+ or Fe.sup.3+ and X is OH or O.sup..crclbar., which comprises culturing Pseudomonas sp. No. 57-250, FERM BP-5143, in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and extracting and collecting said compound from the culture.

### Claim 11 (depends on 10)

A process for replacing the metal ion M.degree. in the compound of claim 10, comprising reacting a solution of said compound with a solution containing a divalent or trivalent metal ion M to obtain a compound containing said metal ion M.