# US 5,707,829 A · DNA sequences and secreted proteins encoded thereby

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- Number: US 5,707,829 A
- Document ID: US5707829A
- Status: Granted
- Kind: A
- Application number: 08/514,014
- Filed: 1995-08-11
- Granted: 1998-01-13
- Earliest claimed: 1995-08-11
- Assignees: Genetics Institute, Inc.
- Inventors: Kenneth Jacobs; Kerry Kelleher; McKeough Carlin; John M. McCoy
- Web page: https://patentgrep.com/patent/US5707829A

## CPC

- C07K 14/523: {Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2}
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 5/00: Drugs for disorders of the endocrine system
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/06: Antiasthmatics
- A61P 21/04: for myasthenia gravis
- A61P 27/02: Ophthalmic agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/10: Antimycotics
- A61P 31/14: for RNA viruses
- A61P 31/18: for HIV
- A61P 31/20: for DNA viruses
- A61P 31/22: for herpes viruses
- A61P 33/02: Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P 33/06: Antimalarials
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 14/54: Interleukins [IL]
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Novel polynucleotides and the proteins encoded thereby are disclosed.

## Claims

### Claim 1

A composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 38 to nucleotide 1447; and
(b) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2.

### Claim 2 (depends on 1)

A composition of claim 1 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 3 (depends on 2)

A host cell transformed with a composition of claim 2.

### Claim 4 (depends on 3)

The host cell of claim 3, wherein said cell is a mammalian cell.

### Claim 5 (depends on 3)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 3 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 6 (depends on 1)

The composition of claim 1 wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 38 to nucleotide 1447.

### Claim 7 (depends on 1)

The composition of claim 1 wherein said polynucleotide comprises a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2.

### Claim 8

A composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:3 from nucleotide 52 to nucleotide 2034; and
(b) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:4.

### Claim 9 (depends on 8)

A composition of claim 8 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 10 (depends on 8)

The composition of claim 8 wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:3 from nucleotide 52 to nucleotide 2034.

### Claim 11 (depends on 8)

The composition of claim 8 wherein said polynucleotide comprises a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:4.

### Claim 12 (depends on 9)

A host cell transformed with a composition of claim 9.

### Claim 13 (depends on 12)

The host cell of claim 12, wherein said cell is a mammalian cell.

### Claim 14 (depends on 12)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 12 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 15

A composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:5 from nucleotide 76 to nucleotide 474; and
(b) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:6.

### Claim 16 (depends on 15)

A composition of claim 15 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 17 (depends on 16)

A host cell transformed with a composition of claim 16.

### Claim 18 (depends on 17)

The host cell of claim 17, wherein said cell is a mammalian cell.

### Claim 19 (depends on 17)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 17 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 20 (depends on 15)

The composition of claim 15 wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:5 from nucleotide 76 to nucleotide 474.

### Claim 21 (depends on 20)

The composition of claim 20 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 22 (depends on 21)

A host cell transformed with a composition of claim 21.

### Claim 23 (depends on 22)

The host cell of claim 22, wherein said cell is a mammalian cell.

### Claim 24 (depends on 22)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 22 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 25 (depends on 15)

The composition of claim 15 wherein said polynucleotide comprises a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:6.

### Claim 26 (depends on 25)

The composition of claim 25 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 27 (depends on 26)

A host cell transformed with a composition of claim 26.

### Claim 28 (depends on 27)

The host cell of claim 27, wherein said cell is a mammalian cell.

### Claim 29 (depends on 27)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 27 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 30

A composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:7 from nucleotide 67 to nucleotide 348; and
(b) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:8.

### Claim 31 (depends on 30)

A composition of claim 30 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 32 (depends on 31)

A host cell transformed with a composition of claim 31.

### Claim 33 (depends on 32)

The host cell of claim 32, wherein said cell is a mammalian cell.

### Claim 34 (depends on 32)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 32 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 35 (depends on 31)

The composition of claim 31 wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:7 from nucleotide 67 to nucleotide 348.

### Claim 36 (depends on 30)

The composition of claim 30 wherein said polynucleotide comprises a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:8.

### Claim 37

A composition comprising an isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:9 from nucleotide 75 to nucleotide 356; and
(b) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:10.

### Claim 38 (depends on 37)

A composition of claim 37 wherein said polynucleotide is operably linked to an expression control sequence.

### Claim 39 (depends on 38)

A host cell transformed with a composition of claim 38.

### Claim 40 (depends on 39)

The host cell of claim 39, wherein said cell is a mammalian cell.

### Claim 41 (depends on 39)

A process for producing a protein, which comprises:
(a) growing a culture of the host cell of claim 39 in a suitable culture medium; and
(b) purifying the protein from the culture.

### Claim 42 (depends on 37)

The composition of claim 37 wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:9 from nucleotide 75 to nucleotide 356.

### Claim 43 (depends on 37)

The composition of claim 37 wherein said pulynucleotide comprises a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:10.

### Claim 44

A composition comprising an isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, and SEQ ID NO:9.