# US 5,707,654 A · Sugar- and sodium-free effervescent tablets and granules and process for preparing same

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- Number: US 5,707,654 A
- Document ID: US5707654A
- Status: Granted
- Kind: A
- Application number: 08/513,973
- Filed: 1995-09-07
- Granted: 1998-01-13
- Earliest claimed: 1993-03-10
- Assignees: Beres Reszvenytarsasag
- Inventors: Jozsef Beres; Jozsef Beres; Laszlo Lex; Istvanne Barkanyi
- Web page: https://patentgrep.com/patent/US5707654A

## CPC

- A61K 9/16: Agglomerates; Granulates; Microbeadlets {; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction (A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51)}
- A23L 2/395: in a particular shape or form
- A23L 2/40: Effervescence-generating compositions
- A61K 9/0007: {Effervescent (A61K9/0065 takes precedence)}
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/34: Copper; Compounds thereof
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)

## Abstract

The invention relates to effervescent tablets and granules comprising a shell material, a basic sparkling component, an acidic sparkling component, and a sweetening agent, macro- and microelements and vitamins as active agents. The effervescent tablets and granules comprise 20-50% by mass of mannitol as shell material, 8-25% by mass of potassium hydrogen carbonate as basic sparkling component, 9-27% by mass of malic acid as acidic sparkling component, and 0.4-2.2% by mass of aspartame as sweetening agent. Furthermore, the invention relates to a process for preparing the above-described effervescent tablets and granules.

## Claims

### Claim 1

Effervescent tablets and granules comprising 20-50% by mass of mannitol as shell material, 8-25% by mass of potassium hydrogen carbonate as basic sparkling component, 9-27% by mass of malic acid as acidic sparkling component, 0.4-2.2% by mass of aspartame as sweetening agent, magnesium, zinc, iron(II), copper(II), manganese(II) and chromium(III) cations, molybdenum(VI) and selenium(IV) anions as macro and trace elements, and optionally vitamins as active agents, and flavoring and lubricating additives used in the manufacture of effervescent tablets in an amount necessary to supplement the mass of the components to 100%.

### Claim 2 (depends on 1)

Effervescent tablets or granules as defined in claim 1, which comprise 30-40% by mass of mannitol, 14-18% by mass of potassium hydrogen carbonate, 15-21% by mass of malic acid, and 0.6-1.5% by mass of aspartame.

### Claim 3

A process for preparing effervescent tablets or granules comprising the steps of homogenizing 20-50% by mass of mannitol, 8-25% by mass of potassium hydrogen carbonate, 9-24 by mass of malic acid, and 0.4-2.2% by mass of aspartame together with the magnesium, zinc, iron(II), copper(II), manganese(II) and chromium(III) cations, molybdenum(VI) and selenium(IV) anions and vitamins to be introduced and optionally together with flavoring, lubricating and additives used in the manufacture of effervescent tablets, then granulating the thus-obtained homogenizate to granules ready for compressing, and finally compressing tablets or granules of the desired size and strength.

### Claim 4 (depends on 1)

Effervescent tablets or granules as defined in claim 1, wherein the iron ions are contained in the form of ferrosulphate heptahydrate, the zinc ions in the form of zinc sulphate heptahydrate, the copper ions in the form of copper sulphate pentahydrate, the manganese ions in the form of manganese sulphate monohydrate, the molybdenum ions in the form of ammonium heptamolybdenate tetrahydrate, the selenium ions in the form of selenious acid, the magnesium ions in the form of magnesium sulphate heptahydrate, and the chromium ions in the form of chromium(III) chloride hexahydrate.

### Claim 5 (depends on 1)

Effervescent tablets or granules as claimed in claim 1, wherein the vitamins are present in the following amounts related to the mass of the composition: 0.01-0.5% by mass of vitamin B.sub.1, 0.01-0.25% by mass of vitamin B.sub.2, 0.01-0.5% by mass of vitamin B.sub.6, 0.001-0.01% by mass of vitamin B.sub.12, 0.1-2% by mass of nicotinamide, 0.01-0.5% by mass of vitamin A, 0.0015-0.015% by mass of vitamin D, 0.1-5% by mass of vitamin C, 0.01-0.1% by mass of folic acid, 0.1-0.5% by mass of pantothenic acid, 0.01-7% by mass of vitamin E and 0.001-0.01% by mass of vitamin H.

### Claim 6 (depends on 3)

A process as defined in claim 3, in which 30-40% by mass of mannitol, 14-18% by mass of potassium hydrogen carbonate, 15-21% by mass of malic acid, and 0.6-1.5% by mass of aspartame are homogenized with the other components of the tablet.