Transparent liquid for encapsulated drug delivery
AssigneeLDS Technologies, Inc.
InventorSeang H. Yiv
Life of this patent
Estimating the term…
Abstract
There is provided a stable transparent multi-component composition useful for the delivery of water soluble active agents to animals. The compositions are formulated with a mixture of an oil phase, an aqueous phase, and a surfactant system, along with the active agent to be delivered to the animal. The compositions are specially formulated to be compatible with capsules such as gelatin and starch capsules. The aqueous phase of the compositions contains a substantial amount of polyethylene glycol and can optionally also contain a plasticizer. Preferred active agents are proteinaceous materials.
Claims45
A stable, transparent drug delivery composition suitable for storage and administration of biologically active materials, comprising:
- (a) a delivery composition comprising:
- (1) from about 1 to about 80 weight percent of a pharmaceutically acceptable oil phase;
- (2) from about 3 to about 98 weight percent surfactant;
- (3) from about 2 to about 60 weight percent polyethylene glycol;
- (4) from about 0.5 to about 15 weight percent water;
- and
- (b) a therapeutically effective amount of a biologically active material having an octanol:water partition coefficient of less than about 0.1;
- provided that the composition does not contain a mixture of cholesterol and phospholipid, and wherein the ratio of the polyethylene glycol to water is at least 2:1.
A stable, transparent delivery composition, comprising:
- (a) from about 5 to about 70 weight percent of a pharmaceutically acceptable oil phase;
- (b) from about 10 to about 80 weight percent surfactant;
- (c) from about 5 to about 60 weight percent of an aqueous phase comprising from about 60 to about 95 weight percent polyethylene glycol, from about 2 to about 30 weight percent water, and from about 1 to about 15 weight percent plasticizer comprising sorbitol, mannitol, glycerin, sucrose, fructose, glucose, or lactose;
- and
- wherein the ratio of the polyethylene glycol to water is at least 2:1, provided that the composition does not contain a mixture of cholesterol and phospholipid.
A method of administering an encapsulated drug delivery composition, comprising:
- providing a capsule within which is contained a drug delivery composition comprising:
- (a) a delivery composition comprising:
- (1) from about 5 to about 70 weight percent of an oil phase;
- (2) from about 5 to about 60 weight percent of an aqueous phase consisting essentially of water, polyethylene glycol, and at least one plasticizer, said aqueous phase comprising from about 2 to about 30 weight percent water, from about 60 and 95 weight percent polyethylene glycol, and from about 1 to about 15 weight percent plasticizer comprising sorbitol, mannitol, or glycerin;
- (3) from about 15 to about 75 weight percent of a surfactant mixture;
- and
- (b) a therapeutically effective amount of a biologically active therapeutic material having an octanol:water partition coefficient of less than about 0.1;
- and provided that the delivery composition does not contain a mixture of cholesterol and phospholipid;
- and
- administering said encapsulated drug delivery composition either orally, rectally, or vaginally to the body of an animal.
Dependencies are inferred from the claim text.