# US 5,707,646 A · Taste masking pharmaceutical composition

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- Number: US 5,707,646 A
- Document ID: US5707646A
- Status: Granted
- Kind: A
- Application number: 08/295,672
- Filed: 1994-09-09
- Granted: 1998-01-13
- Earliest claimed: 1992-03-12
- Assignees: Taisho Pharmaceutical Co., Ltd.
- Inventors: Toshio Yajima; Kuniaki Ishii; Nobuo Umeki; Shigeru Itai; Hidefumi Hayashi; Kimihide Shimano; Ikuo Koyama
- Web page: https://patentgrep.com/patent/US5707646A

## CPC

- A61K 9/1617: {Organic compounds, e.g. phospholipids, fats}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 9/1635: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A composition for oral preparations, having a complex formed by dispersing or dissolving an unpleasantly tasting basic drug and a functional polymer compound in a substance having a low melting point, 10 to 70% by weight, based on the composition, of sugar alcohol and 0.1 to 7% by weight, based on the composition, of basic oxide. The composition for oral preparation is excellent in masking unpleasantly tasting basic drugs and has excellent performance in biological use.

## Claims

### Claim 1

A composition for oral preparations, which comprises:
a) a complex formed by dispersing or dissolving an unpleasantly tasting basic drug and a functional polymer compound in a substance having a melting point of 40.degree. to 120.degree. C., wherein the functional polymer compound is selected from the group consisting of Eudragit.RTM. E, AEA (polyvinylacetal diethylaminoacetate) and mixtures thereof,
b) 10 to 70% by weight, based on the composition, of sugar alcohol, and
c) 0.1 to 7% by weight, based on the composition, of basic oxide.

### Claim 2 (depends on 1)

A composition according to claim 1, wherein the complex is obtained by melt- or heat-granulating a functional polymer compound dispersed or dissolved in a heat-melted substance having a melting point of 40.degree. to 120.degree. C. and a basic drug.

### Claim 3 (depends on 1)

A composition according to claim 1, wherein the functional polymer compound is contained in an amount of 1 to 60% by weight based on the complex.

### Claim 4 (depends on 1)

A composition according to claim 1, wherein the basic drug is one of unpleasantly tasting macrolides.

### Claim 5 (depends on 1)

A composition according to claim 1, wherein the substance having a low melting point is a pharmaceutically acceptable substance having a melting point of 40.degree. to 120.degree. C. and being insoluble or sparingly soluble in water.

### Claim 6 (depends on 1)

A composition according to claim 1, wherein the basic oxide is magnesium oxide.

### Claim 7 (depends on 1)

A composition according to claim 1, which has a form of dry syrup.

### Claim 8 (depends on 1)

A composition according to claim 1, wherein the basic oxide is selected from the group consisting of magnesium oxide and aluminum oxide.

### Claim 9 (depends on 8)

The composition of claim 8, wherein the functional polymer is Eudragit.RTM. E (methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer).