Small particle compositions for intranasal drug delivery
AssigneeDanbiosyst UK Limited
InventorLisbeth Illum
Life of this patent
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Abstract
A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 .mu.m to 10 .mu.m. The microspheres may be of starch, gelatin, dextran, collagen or albumin. Suitable drags include peptides, such as insulin, and antigenic vaccine ingredients. The composition may additionally comprise an absorption enhancer. The microspheres are administered m the nasal cavity by a means such that the product of the square of the microsphere diameter and the flow rate is greater than 2000 .mu.m.sup.2.liters/min.
Claims13
A method for systemically delivering an active drug to a mammal, the method comprising:
- a) providing a composition comprising a plurality of bioadhesive microspheres comprising a material selected from the group consisting of polysaccharides, proteins, and synthetic polymers, wherein the polysaccharide is selected from the group consisting of a starch, a dextran, a hyaluronic acid, a gellan gum and pectin and the protein is selected from the group consisting of gelatin, albumin, and collagen, and an active drug selected from the group consisting of proteins and peptides, and non-protein drugs selected from the group consisting of antibiotics, anesthetics, vasoconstrictors, cardiotonics, vasodilators, antiseptics, bone metabolism controlling agents, hypotensives, sedatives, anti-tumour agents, anti-inflammatory agents, anti-histaminic agents, anti-allergic agents, and antitussive-expectorant agents, wherein at least 90 wt % of the microspheres in the composition have a diameter between 0.1 .mu.m and 10 .mu.m;
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- b) administering the composition to a mammal intranasally thereby to systemically delivery a therapeutically effective amount of the drag to the mammal.
Dependencies are inferred from the claim text.