Finely divided solid crystalline powders via precipitation into an anti-solvent
AssigneePharmacia & Upjohn Company
InventorWilliam J. Schmitt
Life of this patent
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Abstract
The present invention is a process for producing a finely divided solid which comprises (1) dissolving the solid to be finely divided in a liquid carrier solvent to form an injection solution and (2) adding the injection solution of step (1) to a volume of anti-solvent sufficient to precipitate or crystallize the solid. The solid can be a pharmaceutical, agricultural chemical, commercial chemical, fine chemical, food item, photographic chemical, dye, explosive, paint, polymer or cosmetic.
Claims26
A process for producing a non-sterile freely divided solid of less than or equal to 30 microns selected from the group consisting of a pharmaceutical, agricultural chemical, commercial chemical, free chemical, food item, photographic chemical, dye, explosive, polymer or cosmetic which comprises:
- (1) dissolving the solid to be finely divided in a liquid carrier solvent to form an injection solution and
- (2) adding the injection solution of step (1) to a volume of anti-solvent sufficient to precipitate or crystallize the solid, where the anti-solvent is selected from the group consisting of carbon dioxide, ethane, ethylene, nitrous oxide, fluoroform (CHF.sub.3), dimethyl ether, propane, butane, isobutanes, propylene, chlorotrifluormethane (CClF.sub.3), sulfur hexafluoride (SF.sub.6), bromotrifluoromethane (CBrF.sub.3), chlorodifluoromethane (CHClF.sub.2), hexafluoroethane, carbon tetrafluoride and mixtures thereof where the finely divided solid is of substantially the same purity as was the pharmaceutical, agricultural chemical, commercial chemical, fine chemical, food item, photographic chemical, dye, explosive, polymer or cosmetic starting material.
A process for producing a finely divided sterile solid of less than or equal to 30 microns selected from the group consisting of a pharmaceutical, agricultural chemical, commercial chemical, free chemical, food item, photographic chemical, dye, explosive, polymer or cosmetic which comprises:
- (1) dissolving the solid to be finely divided in a liquid carrier solvent to form an injection solution,
- (2) passing the injection solution through a sterilizing filter,
- (3) passing an anti-solvent through a sterilizing filter;
- where the anti-solvent is selected from the group consisting of carbon dioxide, ethane, ethylene, nitrous oxide, fluoroform (CHF.sub.3), dimethyl ether, propane, butane, isobutanes, propylene, chlorotrifluormethane (CClF.sub.3), sulfur hexafluoride (SF.sub.6), bromotrifluoromethane (CBrF.sub.3), chlorodifluoromethane (CHClF.sub.2), hexafluoroethane, carbon tetrafluoride and mixtures thereof,
- (4) adding the injection solution of step (2) to a volume of anti-solvent of step (3) sufficient to precipitate or crystallize the solid in a sterilized pressure vessel, where the finely divided solid is of substantially the same purity as was the pharmaceutical, agricultural chemical, commercial chemical, free chemical, food item, photographic chemical, dye, explosive, polymer or cosmetic starting material.
Dependencies are inferred from the claim text.