Integrated planar liquid handling system for maldi-TOF MS
AssigneeHewlett-Packard Company
InventorsJames A. Apffel, John A. Chakel, William S. Hancock, Kay Lichtenwalter
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Abstract
An integrated liquid sample handling system for matrix-assisted laser-desorption/ionization time-of-flight mass spectroscopy (MALDI-TF MS) is described. The integrated system comprises a miniaturized sample handling compartment containing a MALDI ionization surface for separating, chemically manipulating and detecting analytes by MALDI -TOF MS. The miniaturized integrated sample handling system disclosed herein is applicable to a wide range of analytical problems that require separation and/or chemical manipulation of a sample prior to mass analysis as part of the analytical procedure.
Claims9
An integrated liquid handling system for a MALDI-TOF mass spectrometer comprising a thin film support having an upper surface and a lower surface, said upper surface including a sample handling compartment and said lower surface including means for moving an analyte and fluids within said compartment, wherein said sample handling compartment comprises:
- a reservoir for receiving fluid substances;
- a MALDI ionization surface;
- and
- a microchannel for interconnecting said reservoir and said ionization surface.
Dependencies are inferred from the claim text.