# US 5,705,710 A · Process for the synthesis of hexafluoroisopropyl ethers > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,705,710 A - Document ID: US5705710A - Status: Granted - Kind: A - Application number: 08/783,758 - Filed: 1997-01-15 - Granted: 1998-01-06 - Earliest claimed: 1997-01-15 - Assignees: University of Iowa Research Foundation - Inventors: Max T. Baker; John H. Tinker; Jan A. Ruzicka - Web page: https://patentgrep.com/patent/US5705710A ## CPC - C07C 41/22: by introduction of halogens; by substitution of halogen atoms by other halogen atoms - C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS ## Abstract This invention relates to a method of synthesizing 1,1,1,3,3,3-hexafluoroisopropyl ether compounds from the reaction of methoxymalanonitrile with a bromine trifluoride composition. ## Claims ### Claim 1 A method of synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether comprising the reaction of methoxymalononitrile with a bromine trifluoride composition. ### Claim 2 (depends on 1) A method of synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 1, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition at temperatures between approximately 20.degree. C. and 60.degree. C. ### Claim 3 (depends on 2) A method of synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 2, comprising having the reaction of a bromine trifluoride composition with methoxymalononitrile in the absence of a solvent. ### Claim 4 (depends on 3) A method of synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 3, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition comprised of BrF, BrF.sub.2, BrF.sub.3, BrF.sub.4 and Br.sub.2. ### Claim 5 (depends on 4) A method of synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 4, comprising having the reaction of a bromine trifluoride composition with methoxymalononitrile in a sealed vessel with the components liquified and agitated, and discharging gas products via a cold trap to condense and collect the said methyl 1,1,1,3,3,3-hexafluoroisopropyl ether. ### Claim 6 A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) by reacting methoxymalononitrile with a bromine trifluoride composition. ### Claim 7 (depends on 6) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to claim 6, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition at temperatures between approximately 20.degree. C. and 60.degree. C. ### Claim 8 (depends on 7) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to claim 7, comprising having the reaction of a bromine trifluoride composition with methoxymalononitrile in the absence of a solvent. ### Claim 9 (depends on 8) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to claim 8, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition comprised of BrF, BrF.sub.2, BrF.sub.3, BrF.sub.4 and Br.sub.2. ### Claim 10 (depends on 9) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to claim 9, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition in a sealed vessel with the components liquified and agitated, and discharging gas products via a cold trap to condense and collect the said sevoflurane. ### Claim 11 (depends on 5) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane), comprising first synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 5, and then returning the synthesized methyl 1,1,1,3,3,3-hexafluoroisopropyl ether to the sealed vessel and bromine trifluoride composition for synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to the continuation of the reaction of claim 5. ### Claim 12 A method of simultaneously synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) and methyl 1,1,1,3,3,3-hexafluoroisopropyl ether by reacting methoxymalononitrile with a bromine trifluoride composition. ### Claim 13 (depends on 12) A method of simultaneously synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) and methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 12, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition at temperatures between approximately 20.degree. C. and 60.degree. C. ### Claim 14 (depends on 13) A method of simulaneously synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) and methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 13, comprising having the reaction of a bromine trifluoride composition with methoxymalononitrile in the absence of a solvent. ### Claim 15 (depends on 14) A method of simultaneously synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) and methyl 1,1,1,3,3,3-hexafluoroisopropyl ether according to claim 14, comprising having the reaction of of methoxymalononitrile with a bromine trifluoride composition comprised of BrF, BrF.sub.2, BrF.sub.3, BrF.sub.4 and Br.sub.2. ### Claim 16 (depends on 15) A method of simultaneously synthesizing methyl 1,1,1,3,3,3-hexafluoroisopropyl ether and fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to claim 15, comprising having the reaction of methoxymalononitrile with a bromine trifluoride composition in a sealed vessel with the components liquidified and agitated, and discharging gas products via a cold trap to condense and collect the said ethers. ### Claim 17 (depends on 16) A method of synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane), according to claim 16, comprising returning the synthesized methyl 1,1,1,3,3,3-hexafluoroisopropyl ether back to the sealed vessel and bromine trifluoride for synthesizing fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) according to the continuation of the reaction of claim 16.