# US 5,705,659 A · Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof

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- Number: US 5,705,659 A
- Document ID: US5705659A
- Status: Granted
- Kind: A
- Application number: 08/671,789
- Filed: 1996-06-20
- Granted: 1998-01-06
- Earliest claimed: 1994-09-30
- Assignees: Korea Institute of Science and Technology
- Inventors: Hokoon Park; Sun Ho Jung; Yong Sup Lee; Ki Hong Nam
- Web page: https://patentgrep.com/patent/US5705659A

## CPC

- C07C 69/734: Ethers
- C07C 69/738: Esters of keto-carboxylic acids {or aldehydo-carboxylic acids}
- C07F 7/081: {comprising at least one atom selected from the elements N, O, halogen, S, Se or Te}
- C07F 7/1804: {Compounds having Si-O-C linkages (Si-O-acyl linkages C07F7/1896)}
- C07F 7/2208: {Compounds having tin linked only to carbon, hydrogen and/or halogen}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, t-butyldimethylsilyl, triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epi-stereoisomeric mixture.

## Claims

### Claim 1

A compound represented as formula I: ##STR7## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl t-butyldimethylsilyl, triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or an acetyl group; P is hydrogen, trimethylsilyl or tri-n-butylin; and the wavy line indicates an epi-stereoisomeric mixture.

### Claim 2 (depends on 1)

The compound in accordance with claim 1, wherein the R.sup.1 and R.sup.2 are acetyl, and the P is hydrogen.