# US 5,705,647 A · Intermediates for making HIV-protease inhibitors

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- Number: US 5,705,647 A
- Document ID: US5705647A
- Status: Granted
- Kind: A
- Application number: 08/708,607
- Filed: 1996-09-05
- Granted: 1998-01-06
- Earliest claimed: 1996-09-05
- Assignees: Agouron Pharmaceuticals, Inc.; Japan Tobacco Inc.
- Inventors: Srinivasan Babu; Bennett C. Borer; Travis P. Remarchuk; Robert J. Szendroi; Kathleen R. Whitten; Juliette K. Busse; Kim F. Albizati
- Web page: https://patentgrep.com/patent/US5705647A

## CPC

- C07D 233/22: Radicals substituted by oxygen atoms
- A61P 31/12: Antivirals
- A61P 31/18: for HIV
- C07D 413/04: directly linked by a ring-member-to-ring-member bond
- C07D 413/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive intermediates.

## Claims

### Claim 1

A compound of formula 10: ##STR46## wherein R.sup.3 is aryl or alkyl; or a pharmaceutically acceptable salt or solvate thereof.

### Claim 2

A compound of formula 8a: ##STR47## wherein R.sup.4 is alkyl; or a pharmaceutically acceptable salt or solvate thereof.

### Claim 3

A compound of formula 9a: ##STR48## wherein R.sup.4 is alkyl; or a pharmaceutically acceptable salt or solvate thereof.

### Claim 4 (depends on 2)

A compound according to claim 2, wherein R.sup.4 is a methyl group.