# US 5,705,640 A · O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same

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- Number: US 5,705,640 A
- Document ID: US5705640A
- Status: Granted
- Kind: A
- Application number: 08/596,496
- Filed: 1996-02-05
- Granted: 1998-01-06
- Earliest claimed: 1995-02-11
- Assignees: Yukong Limited
- Inventors: Yong Moon Choi; Dong Il Han; Yong Kil Kim
- Web page: https://patentgrep.com/patent/US5705640A

## CPC

- C07D 295/205: Radicals derived from carbonic acid
- C07C 271/12: to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07B 2200/07: Optical isomers
- C07C 2601/02: with a three-membered ring
- C07C 2601/14: The ring being saturated
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

The present invention relates to O-carbamoyl-(D)-phenylalaninol compound represented by the following structural formula V and pharmaceutically acceptable salts thereof to treat diseases of the central nervous system: ##STR1## wherein R.sup.1 and R.sup.2 may be the same with or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl containing 1 to 8 carbon atoms, and 5 to 7-membered aliphatic cyclic compounds which may comprise not more than two nitrogen or oxygen atoms directly unconnected, the total number of carbon atom of R.sup.1 and R.sup.2 ranging from 0 to 16.

## Claims

### Claim 1

An O-carbamoyl-(D)-phenylalaninol compound, represented by the following structural formula V: ##STR10## wherein R.sup.1 and R.sup.2 may be the same as or different from each other and are independently selected from the group consisting of hydrogen and lower alkyl containing 1 to 8 carbon atoms, and wherein R.sup.1 and R.sup.2 may be joined to form a 5 to 7-membered aliphatic cyclic radical which may comprise 0 to 1 additional nitrogen or 0 to 1 oxygen atoms directly unconnected, and the pharmaceutically acceptable salts thereof.

### Claim 2 (depends on 1)

The compound in accordance with claim 1, wherein O-carbamoyl-(D)-phenylalaninol of the structural formula V comprises the compounds having the following general formulas: ##STR11##