# US 5,705,630 A · 2'-methylidenepyrimidine nucleoside compounds

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- Number: US 5,705,630 A
- Document ID: US5705630A
- Status: Granted
- Kind: A
- Application number: 07/818,656
- Filed: 1992-01-07
- Granted: 1998-01-06
- Earliest claimed: 1988-08-25
- Assignees: Yoshitomi Pharmaceutical Industries, Ltd.; Yamasa Shoyu Kabushiki Kaisha
- Inventors: Tohru Ueda; Takuma Sasaki; Akira Matsuda; Keiji Yamagami; Akihiro Fujii
- Web page: https://patentgrep.com/patent/US5705630A

## CPC

- C07H 19/06: Pyrimidine radicals
- C07H 19/10: with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)

## Abstract

2'-Methylidenepyrimidine nucleoside compounds of the general formula: ##STR1## wherein R.sup.1 stands for amino or hydroxy group; R.sup.2 stands for a halogen or a lower alkyl when R.sup.1 is amino or R.sup.2 stands for an alkyl having 2 to 4 carbon atoms, an alkynyl having 2 to 4 carbon atoms or a haloalkyl when R.sup.1 is hydroxy group; and R.sup.3 stands for hydrogen or a phosphoric acid residue, or salts thereof, anticancer compositions containing one or more of these compounds and methods for production of these compounds. Said compounds and salts thereof exhibit noticeable antitumor activities and are useful as anticancer agents.

## Claims

### Claim 1

A 2'-methylidenepyrimidine nucleoside selected from the group consisting of (1) a compound of the formula ##STR6## wherein R.sup.3 is hydrogen, (2) a salt of said compound and (3) a hydrate of said compound.