# US 5,705,626 A · Cloned glutamic acid decarboxylase nucleic acids

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- Number: US 5,705,626 A
- Document ID: US5705626A
- Status: Granted
- Kind: A
- Application number: 08/485,718
- Filed: 1995-06-07
- Granted: 1998-01-06
- Earliest claimed: 1990-09-21
- Assignees: The Regents of the University of California
- Inventors: Allan J. Tobin; Mark G. Erlander; Daniel L. Kaufman
- Web page: https://patentgrep.com/patent/US5705626A

## CPC

- G01N 33/564: for pre-existing immune complex or autoimmune disease {, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9}
- C12N 9/88: Lyases (4.)
- C12Y 401/01015: Glutamate decarboxylase (4.1.1.15)
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- G01N 2800/042: Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
- G01N 2800/24: Immunology or allergic disorders
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention is directed to isolated polypeptides useful in ameliorating autoimmune disease.

## Claims

### Claim 1

An isolated polynucleotide sequence encoding the polypeptide of the amino acid sequence:
X-Pro-Glu-Val-Lys-Y-Lys-Z
wherein X is an amino acid sequence selected from one to ten amino acids or omitted; Y is Glu; and Z is an amino acid sequence selected from one to eight amino acids or omitted wherein the polypeptide stimulates in vitro proliferation of human T lymphocytes.

### Claim 2 (depends on 1)

The polynucleotide of claim 1 which is DNA.

### Claim 3 (depends on 2)

The polynucleotide of claim 2 which is cDNA.

### Claim 4 (depends on 1)

A polynucleotide according to claim 1, wherein X comprises Lys, Y is Glu and Z comprises Leu.

### Claim 5 (depends on 4)

The polynucleotide according to claim 4, wherein X further comprises Met and Z further comprises Arg and Leu.

### Claim 6 (depends on 1)

The polynucleotide according to claim 1, wherein X is the amino acid sequence Ala-Met-Met-Ile-Ala-Arg-Phe-Lys-Met-Phe and Z is the amino acid sequence Gly-Met-Ala-Ala-Leu-Pro-Arg-Leu.