# US 5,705,625 A · Nucleic Acid Encoding novel protein tyrosine kinase

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- Number: US 5,705,625 A
- Document ID: US5705625A
- Status: Granted
- Kind: A
- Application number: 08/357,598
- Filed: 1994-12-15
- Granted: 1998-01-06
- Earliest claimed: 1994-12-15
- Assignees: The Johns Hopkins University School of Medicine
- Inventors: Curt I. Civin; Donald Small; Meredith G. Safford
- Web page: https://patentgrep.com/patent/US5705625A

## CPC

- C12N 9/1205: {Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases}
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 35/02: specific for leukemia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 48/00: Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A novel protein tyrosine kinase, JAK3, and a polynucleotide sequence encoding JAK3 polypeptide are disclosed herein. JAK3 is a new member of the JAK family of protein tyrosine kinases which are important in regulation of cellular proliferation and differentiation. Also disclosed are therapeutic methods utilizing JAK3 polypeptide and polynucleotide sequences.

## Claims

### Claim 1

An isolated polynucleotide sequence comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO:2.

### Claim 2 (depends on 1)

The isolated polynucleotide sequence of claim 1, comprising a polynucleotide sequence encoding a polypeptide having an amino acid sequence of SEQ ID NO:2 and having at least one epitope for an antibody immunoreactive with JAK3.

### Claim 3 (depends on 1)

A host cell which contains the polynucleotide of claim 1 in an expression vector.

### Claim 4 (depends on 1)

A recombinant expression vector which contains the polynucleotide of claim 1.

### Claim 5

An isolated polynucleotide sequence, wherein the nucleotide sequence is selected from the group consisting of:
a) SEQ ID NO:1; and
b) nucleic acid sequences encoding a polypeptide according to SEQ ID NO:2.