# US 5,705,615 A · Antibodies specific for HT.sub.m4

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- Number: US 5,705,615 A
- Document ID: US5705615A
- Status: Granted
- Kind: A
- Application number: 08/707,340
- Filed: 1996-09-03
- Granted: 1998-01-06
- Earliest claimed: 1994-10-06
- Assignees: Beth Israel Deaconess Medical Center, Inc.
- Inventors: Bing Lim; Chaker N. Adra; Jean-Michel Lelias
- Web page: https://patentgrep.com/patent/US5705615A

## CPC

- C07K 14/70596: {Molecules with a "CD"-designation not provided for elsewhere}
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 13/12: of the kidneys
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/22: for herpes viruses
- A61P 35/00: Antineoplastic agents
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to a recombinant DNA molecule which encodes a HT.sub.m4 protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT.sub.m4 protein and a recombinant HT.sub.m4 protein. The invention also relates to a method for detecting the presence of a hereditary atopy.

## Claims

### Claim 1

An antibody which binds to a HT.sub.m4 protein.

### Claim 2 (depends on 1)

The antibody of claim 1 which binds to a cytoplasmic carboxyl terminal domain of HT.sub.m4.

### Claim 3 (depends on 1)

The antibody of claim 1 which binds a phosphorylation site in a cytoplasmic carboxyl terminal domain of HT.sub.m4 at an epitope specific for KAP.

### Claim 4 (depends on 1)

The antibody of claim 1 which binds an epitope of HT.sub.m4 specific for a TNF receptor associated factor selected from the group consisting of TRAF-1, TRAF-2, and TRAF-3.