# US 5,705,526 A · Hypercholesterolemia therapeutic agent

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- Number: US 5,705,526 A
- Document ID: US5705526A
- Status: Granted
- Kind: A
- Application number: 08/603,778
- Filed: 1996-02-20
- Granted: 1998-01-06
- Earliest claimed: 1995-06-15
- Assignees: Mutsunori Fujiwara
- Inventors: Mutsunori Fujiwara; Toru Hiyoshi; Shinzo Makita
- Web page: https://patentgrep.com/patent/US5705526A

## CPC

- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/01: Hydrocarbons
- A61P 3/06: Antihyperlipidemics
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A hypercholesterolemia therapeutic agent containing lycopene as an effective ingredient. The hypercholesterolemia therapeutic agent comprises a soft-capsulated drug, and the soft-capsulated drug comprises a soft capsule which comprises gelatin and glycerin, and contents which comprise lycopene, .beta.-carotene, .alpha.-carotene, d-.alpha. tocopherol and a mixture of a wheat germ oil and a vegetable oil, which contents are packed into the soft capsule.

## Claims

### Claim 1

A method for treating hypercholesterolemia in a patient in need thereof, which comprises:
administering to said patient a hypercholesterolemia therapeutic agent containing lycopene as an effective ingredient therein, wherein said lycopene is administered to said patient in an amount within a range of from 1 to 25 mg per day per adult.

### Claim 2 (depends on 1)

The method of claim 1, wherein:
said hypercholesterolemia therapeutic agent comprises a soft-capsulated drug, with said soft-capsulated drug comprising:
a soft capsule which comprises gelatin and glycerin, and wherein inside said soft-capsule there are contents which comprise (a) lycopene, (b) .beta.-carotene, (c) .alpha.-carotene, (d) d-.alpha. tocopherol and (e) a mixture of a wheat germ oil and a vegetable oil; and which contents are packed into said soft capsule.

### Claim 3 (depends on 2)

The method of claim 2, wherein:
the amount of said lycopene in said soft-capsulated drug is within the range of 1 to 25 mg.

### Claim 4 (depends on 2)

The method of claim 2, wherein:
the amount of said lycopene in said soft-capsulated drug is within the range of from 3 to 15 mg.

### Claim 5 (depends on 2)

The method of claim 2, wherein said components (a) to (d) are present, inside the soft capsule in the following amounts:
______________________________________ lycopene from 1 to 25 mg, .beta.-carotene from 1 to 12.5 mg, .alpha.-carotene from 1 to 12.5 mg, and d-.alpha. tocopherol from 1 to 17 mg. ______________________________________

### Claim 6 (depends on 2)

The method of claim 2, wherein said contents of said soft-capsulated drug consist essentially of:
______________________________________ lycopene 1.5 mg, .beta.-carotene 1.0 mg, .alpha.-carotene 0.5 mg, d-.alpha. tocopherol 5.0 mg, and said mixture of said wheat germ 292.0 mg; and oil and said vegetable oil said soft capsule consists essentially of: gelatin 127.5 mg, and glycerin 22.5 mg. ______________________________________