Thiepane compounds
AssigneeGilead Sciences, Inc.
InventorsLawrence R. McGee, Choung U. Kim, Norbert W. Bischofberger, Steven Krawczyk
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Abstract
Tri- and tetra substituted thiepane and compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.
Claims13
A composition comprising a compound of the formula:
- ##STR197## wherein each W.sub.2 is independently phenyl or thiazole wherein each W.sub.2 is independently substituted with 0 to 1 --OH, --OMe, --NH.sub.2, --N(H)(Me), --N(H)(Et), --N(H)(i-Pr), --N(H)(n-Pr), --N(Me).sub.2, --NO.sub.2, or --CN;
- R.sub.3 is H or R.sub.4 ;
- and
- R.sub.4 is an alkyl of 1 to 6 carbon atoms.
A composition comprising a compound of the formula:
- ##STR201## wherein each W.sub.2 is independently phenyl or thiazole wherein each W.sub.2 is independently substituted with 0 to 1 --OH, --OMe, --NH.sub.2, --N(H)(Me), --N(H)(Et), --N(H)(i-Pr), --N(H)(n-Pr), --N(Me).sub.2, --NO.sub.2, or --CN;
- R.sub.3 is H or R.sub.4 ;
- and
- R.sub.4 is an alkyl of 1 to 6 carbon atoms.
A composition comprising a compound of the formula:
- ##STR204## wherein each W.sub.2 is independently phenyl or thiazole wherein each W.sub.2 is independently substituted with 0 to 1 --OH, --OMe, --NH.sub.2, --N(H)(Me), --N(H)(Et), --N(H)(i-Pr), --N(H)(n-Pr), --N(Me).sub.2, --NO.sub.2, or --CN;
- R.sub.3 is H or R.sub.4 ;
- and
- R.sub.4 is an alkyl of 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.