# US 5,705,520 A · Medicaments

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- Number: US 5,705,520 A
- Document ID: US5705520A
- Status: Granted
- Kind: A
- Application number: 08/651,961
- Filed: 1996-05-21
- Granted: 1998-01-06
- Earliest claimed: 1990-12-12
- Assignees: Glaxo Group Limited
- Inventors: Joanne Craig; Derek Leslie Crookes; Stephen John Skittrall
- Web page: https://patentgrep.com/patent/US5705520A

## CPC

- C07D 209/16: Tryptamines
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/06: Antimigraine agents
- A61P 29/02: without antiinflammatory effect
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention, relates to 3-›2-(dimethylamino)ethyl!-N-methyl-1H-methanesulphonamide sulphate salt (2:1) and pharmaceutically acceptable solvates thereof, and to pharmaceutical compositions containing same. The compound is useful in the treatment of conditions associated with cephalic pain, in particular migraine. The pharmaceutical compositions are particularly useful as intranasal formulations.

## Claims

### Claim 1

3-›2-(dimethylamino)ethyl!-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof.

### Claim 2

A pharmaceutical composition which comprises 3-›2-(dimethylamino)ethyl!-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof as active ingredient together with a pharmaceutically acceptable carrier.

### Claim 3 (depends on 2)

A pharmaceutical composition as claimed in claim 2 adapted for intranasal administration.

### Claim 4

A method of treating a human suffering from or susceptible to cephalic pain which comprises administration of an effective amount of 3-›2-(dimethylamino)ethyl!-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof to the human in need thereof.

### Claim 5 (depends on 4)

A method according to claim 4 wherein the 3-›2-(dimethylamino)ethyl!-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof is administered intranasally.

### Claim 6 (depends on 4)

A method according to claim 4 wherein the 3-›2-(dimethylamino)ethyl!-N-methyl-1H-indole-5-methanesulphonamide hemisulphate salt (2:1) or a physiologically acceptable solvate thereof is administered in the form of an aqueous solution.

### Claim 7 (depends on 4)

A method according to claim 4 wherein the cephalic pain is caused by migraine.