# US 5,705,508 A · Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

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- Number: US 5,705,508 A
- Document ID: US5705508A
- Status: Granted
- Kind: A
- Application number: 08/542,537
- Filed: 1995-10-13
- Granted: 1998-01-06
- Earliest claimed: 1993-03-26
- Assignees: The Research Foundation of State University of New York; Indena SpA of Viale Ortles
- Inventors: Iwao Ojima; Ezio Bombardelli
- Web page: https://patentgrep.com/patent/US5705508A

## CPC

- C07D 305/14: condensed with carbocyclic rings or ring systems
- A61P 35/00: Antineoplastic agents
- C07D 205/08: with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07F 7/1804: {Compounds having Si-O-C linkages (Si-O-acyl linkages C07F7/1896)}
- Y02P 20/55: Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

## Abstract

The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) ##STR1## with .beta.-lactams of formula (V). ##STR2## The invention also provides pharmaceutical compositions including the novel taxanes and methods for treatment of certain cancers with these new compounds.

## Claims

### Claim 1

A compound of the formula (I) ##STR15## wherein R.sup.1 is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl radical, a substituted aryl or heteroaryl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical;
R.sup.2 is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl radical;
or R.sup.2 is an RO--, RS-- or RR'N-- wherein R is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl radical; R' is a hydrogen or R as defined above; R and R' can be connected to form a cyclic structure;
R.sup.3 is a hydrogen or an acyl or an alkyl or an alkenyl or an alkynyl or an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, or an unsubstituted or substituted aryl or heteroaryl radical or a hydroxyl protecting group;
R.sup.4 is a hydrogen or an acyl radical or a carbamoyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.6 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 and R.sup.6 can be connected to form a cyclic structure;
R.sup.7 is an acyl group;
R.sup.8 is an hydrogen or a hydroxyl protecting group.

### Claim 2 (depends on 1)

The compound according to the claim 1 wherein
R.sup.1, R.sup.2 and R are independently a straight chain or branched alkyl radical having 1 to 10 carbon atoms, a straight chain or branched alkenyl radical having 2 to 10 carbon atoms, or a straight chain or branched alkynyl radical having 2 to 10 carbon atoms, a cycloalkyl radical having 3 to 10 carbon atoms, a heterocycloalkyl radical having 3 to 10 carbon atoms, a cycloalkenyl radical having 3 to 10 carbon atoms, a heterocycloalkenyl radical having 3 to 10 carbon atoms, a polycycloalkyl radical having 6 to 20 carbon atoms, an aryl radical having 6 to 20 carbons, a heteroaryl radical having 3 to 15 carbon atoms;
or R.sup.2 is RO--, RS-- or RR'N-- radical wherein R is as defined above,
R' is a hydrogen or R as defined above; R and R' can be connected to form a cyclic structure which has 2 to 10 carbon atoms;
R.sup.3, R.sup.4, R.sup.5 or R.sup.6 are each hydrogen or an acyl radical having 1 to 20 carbons or R as defined above or a hydroxyl protecting group;
R.sup.7 is an acyl group having 1 to 20 carbons;
R.sup.8 is a hydrogen or a hydroxyl protecting group.

### Claim 3 (depends on 1)

The compound of claim 1, wherein said radicals of R.sup.1, R.sup.2 and R are each substituted with at least one halogen, hydroxyl, amino, mercapto, cyano, carboxyl group; alkoxy, alkylamino, dialkylamino, alkylthio, alkoxycarboxyl group wherein said alkyl portion has 1 to 15 carbon atoms; aryloxy, arylthio, aryloxycarbonyl, wherein said aryl portion has 6 to 20 carbon atoms; or heteroarylthio, heteroaryloxy carbonyl wherein said heteroaryl portion has 3 to 15 carbon atoms.

### Claim 4 (depends on 1)

A compound according to claim 1 wherein
R.sup.1 is an alkyl radical selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, heptyl, isoheptyl, octyl, isooctyl, cyclohexylmethyl, cyclohexylethyl, benzyl, phenylethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and adamantyl, or an alkenyl radical selected from the group consisting of vinyl, allyl, 2-phenylethenyl, 2-furylethenyl, 2-pyrrolylethenyl, 2-pyridylethenyl, 2-thienylethyl, or an unsubstituted or substituted alkynyl radical selected from the group consisting of ethynyl and propargyl or an aryl radical selected from the group consisting of phenyl, tolyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 4-chlorophenyl, and naphthyl; or a heteroaryl radical selected from the group consisting of furyl, pyrrolyl, and pyridyl, or a cycloalkenyl radical selected from the group consisting of cyclopentenyl, cyclohexenyl and cycloheptenyl or a heterocycloalkyl selected from the group consisting of oxiranyl, pyrrolidinyl, piperidinyl, tetrahydrofuryl, and tetrahydropyranyl, or a heterocycloalkenyl radical selected from the group consisting of dihydrofuryl, dihydropyrrolyl, dihydropiranyl, and dihydropyridyl;
R.sup.2 is an unsubstituted or substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl radical selected from the group consisting of phenyl, tolyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isopropyl, isobutyl, neopentyl, hexyl, heptyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, phenylethenyl, crotyl, allyl, vinyl, propargyl, pyridinyl, furyl, thienyl, pyrrolidinyl, and piperidinyl;
or R.sup.2 is RO--, RS--, or RR'N-- wherein R is an unsubstituted or substituted alkyl radical selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, heptyl, isoheptyl, octyl, isooctyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and adamantyl, or an alkenyl radical selected from the group consisting of vinyl and allyl, or an aryl radical selected from phenyl and naphthyl, or a heteroaryl radical selected from the group consisting of furyl, pyrrolyl, and pyridyl, or a cycloalkenyl radical selected from the group consisting of cyclopentenyl, cyclohexenyl and cycloheptenyl, or a heterocycloalkyl radical selected from the group consisting of an oxiranyl, tetrahydrofuryl, pyrrolidinyl, piperidinyl, and tetrahydropiranyl, or a heterocycloalkenyl radical selected from the group consisting of dihydrofuryl, dihydropyrrolyl, dihydropiranyl, dihydropyridyl; R' is a hydrogen or R is as defined above; cyclic RR'N-- is a radical including an aziridino, azetidino, pyrrolidino, piperidino or morpholino group;
wherein said hydroxyl protecting group is selected from the group consisting of methoxymethyl, methoxyethyl, 1-ethoxyethyl, benzyloxymethyl, (.beta.-trimethylsilyl-ethoxyl)methyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, 2,2,2-trichloroethoxymethyl, trimethylsilyl, triethylsilyl, tripropylsilyl, dimethylethylsilyl, dimethyl(t-butyl)silyl, diethylmethylsilyl, dimethylphenylsilyl and diphenylmethylsilyl;
said acyl is selected from the group consisting of acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl and trifluoroacetyl, propanoyl, butanoyl, pentanoyl, hexanoyl, heptanoyl, cyclohexanecarbonyl, octanoyl, nonanoyl, decanoyl, undecanoyl, dodecanoyl, benzoyl, phenylacetyl, nanphthalenecarbonyl, indoleacetyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, and butoxycarbonyl; and
R.sup.5 and R.sup.6 form a cyclic structure with two oxygen atoms of the skeleton of said taxane, wherein said cyclic structure is selected from the group consisting of carbonate, methylacetal, ethylacetal, propylacetal, butylacetal, phenylacetal, dimethylketal, diethylketal, dipropylketal, and dibutylketal.

### Claim 5 (depends on 1)

The compound according to claim 1 wherein
R.sup.1 is a tolyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 4-hydroxyphenyl,1-naphthyl, 2-naphthyl, pyridyl, furyl, thienyl, pyrrolyl, N-methylpyrrolyl, 2-phenylethenyl, 2-furylethenyl, 2-pyridylethenyl, 2-thienylethenyl, 2-phenylethyl, 2-cyclohexylethyl, cyclohexylmethyl, isobutyl or cyclohexyl;
R.sup.2 is selected from the group consisting of phenyl, tolyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isopropyl, isobutyl, neopentyl, hexyl, heptyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, and phenylethenyl;
or R.sup.2 is RO-- wherein R is selected from the group consisting of a methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, cyclohexyl, phenyl, benzyl and 9-fluorenylmethyl;
or R.sup.2 is RR'N-- selected from the group consisting of a methylamino, ethylamino, propylamino, isopropylamino, butylamino, isobutylamino, tert-butylamino, neopentylamino, cyclohexylamino, phenylamino or benzylamino, dimethylamino, diethylamino, dipropylamino, dibutylamino, dipentylamino, dihexylamino, dicyclohexylamino, methyl(tert-butyl)amino, cyclohexyl(methyl)amino, methyl(phenyl)amino, pyrrolidiono, piperidino, or morpholino group;
R.sup.3 and R.sup.4 are selected from the group consisting of a hydrogen, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, trifluoroacetyl, benzoyl, phenylacetyl, acryloyl, crotyl, cinnamoyl, allyl, benzyl, methoxymethyl, methoxyethyl, 1-ethoxyethyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluroenylmethoxycarbonyl, trimethylsilyl, triethylsilyl, and (tert-butyl)dimethylsilyl;
R.sup.5 is selected from the group consisting of a hydrogen, acetyl, chloroacetyl, allyl, benzyl, acryloyl, crotyl, and cinnamoyl and R.sup.6 is a hydrogen; wherein R.sup.5 and R.sup.6 are connected to form a cyclic structure selected from the group consisting of carbonyl, propylidene, butylidene, pentylidene, phenylmethylidene, dimethylmethylidene, diethylmethylidene, dipropylmethylidene, dibutylmethylidene, methoxymethylidene, ethoxymethylidene, methylene, ethylene, and propylene;
R.sup.7 is selected from the group consisting of benzoyl and cyclohexanecarbonyl;
R.sup.8 is selected from the group consisting of a hydrogen, 1-ethoxyethyl, 2,2,2-trichloroethoxylcarbonyl, trimethylsilyl, triethylsilyl, and tert-butyldimethylsilyl.

### Claim 6 (depends on 5)

The compound according to claim 5 wherein
R.sup.1 is a 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluoromethyl, 4-trifluoromethylphenyl, furyl, 2-phenylethenyl, 2-phenylethyl, 2-cyclohexylethyl, 2-furylethenyl, 2-phenylethyl, 2-cyclohexylethyl, cyclohexylmethyl or cyclohexyl;
R.sup.1 is selected from the group consisting of phenyl, tolyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isobutyl, pentyl, neopentyl, hexyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, and phenylethenyl;
or R.sup.2 is RO-- wherein R is selected from the group consisting of a methyl, ethyl, butyl, tert-butyl, cyclohexyl, phenyl, and benzyl;
or R.sup.2 is RR'N-- selected from the group consisting of an ethylamino, tert-butylamino, phenylamino, benzylamino, dimethylamino and morpholino group;
R.sup.3 is a hydrogen, triethylsilyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.4 is a hydrogen, acetyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.5 is an acetyl; R.sup.6 is a hydrogen; and
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is benzoyl or cyclohexanecarbonyl;
R.sup.8 is a hydrogen, 1-ethoxyethyl, triethylsilyl, or tert-butyldimethylsilyl.

### Claim 7 (depends on 5)

The compound according to claim 5 wherein
R.sup.1 is a isobutyl, isobutenyl, 1-propenyl or furyl;
R.sup.2 is phenyl or tert-butoxy;
R.sup.3 is a hydrogen, triethylsilyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.4 is a hydrogen, acetyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.5 is an acetyl and R.sup.6 is a hydrogen;
or R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is benzoyl;
R.sup.8 is a hydrogen or 1-ethoxyethyl.

### Claim 8 (depends on 1)

The compound according to claim 1 wherein
R.sup.1 is an isobutyl, isobutenyl, 1propenyl, or furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, or alkoxycarbonyl radical;
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is an arylcarbonyl, alkylcarbonyl, or alkenylcarbonyl radical;
R.sup.8 is a hydrogen.

### Claim 9 (depends on 1)

The compound according to claim 1 wherein
R.sup.1 is an isobutyl, isobutenyl, 1-propenyl, or furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acetyl, propanoyl, cyclopropanecarbonyl, N,N-dimethylcarbamoyl, or methoxycarbonyl;
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is a benzoyl;
R.sup.8 is a hydrogen.

### Claim 10 (depends on 1)

The compound according to claim 1 wherein
R.sup.1 is an isobutyl, isobutenyl, 1-propenyl, or furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, or alkoxycarbonyl radical;
R.sup.5 is a hydrogen;
R.sup.6 is a hydrogen;
R.sup.7 is a benzoyl;
R.sup.8 is a hydrogen.

### Claim 11 (depends on 1)

The compound according to claim 1 wherein
R.sup.1 is an isobutyl, isobutenyl, 1-propenyl, or furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acetyl, propanoyl, cyclopropanecarbonyl, N,N-dimethylcarbamoyl, or methoxycarbonyl;
R.sup.5 is a hydrogen;
R.sup.6 is a hydrogen;
R.sup.7 is a benzoyl;
R.sup.8 is a hydrogen.

### Claim 12

A process for the synthesis of a compound of the formula (I) ##STR16## wherein R.sup.1 is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl, an unsubstituted or substituted aryl or heteroaryl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical;
R.sup.2 is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl;
or R.sup.2 is an RO--, RS-- or RR'N-- wherein R is an unsubstituted or substituted straight chain or branched alkyl, alkenyl or alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl; R' is a hydrogen or R as defined above; R and R' can be connected to form a cyclic structure;
R.sup.3 is a hydrogen or an acyl or an alkyl or an alkenyl or an alkynyl or an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, or an unsubstituted or substituted aryl or heteroaryl radical or a hydroxyl protecting group;
R.sup.4 is a hydrogen or an acyl radical or a carbamoyl radical, or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.6 is a hydrogen or an acyi radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 and R.sup.6 can be connected to form a cyclic structure;
R.sup.7 is an acyl group;
R.sup.8 is an hydrogen or a hydroxyl protecting group; which comprises:
(a) reacting, in the presence of a base, baccatin of the formula (III) ##STR17## wherein G.sub.1, G.sub.2, G.sub.3, or G.sub.4 is independently an acyl or a carbamoyl or an alkyl or an alkenyl or an alkynyl or an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, or an unsubstituted or substituted aryl or heteroaryl radical or a hydroxyl protecting group selected from the group consisting of methoxylmethyl, methoxyethyl, 1-ethoxyethyl, benzyloxymethyl, (.beta.-trimethylsilylethoxyl)methyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluorenyl-methoxycarbonyl, 2,2,2-trichloroethoxymethyl, trimethylsilyl, triethylsilyl, tripropylsilyl, dimethylethylsilyl, dimethyl(t-butyl)silyl, diethylmethylsilyl, dimethylphenylsilyl and diphenylmethylsilyl;
said acyl radical selected from the group consisting of acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, trifluoroacetyl, propanoyl, butanoyl, pentanoyl, hexanoyl, heptanoyl, cyclohexanecarbonyl, octanoyl, nonanoyl, decanoyl, undecanoyl, dodecanoyl, benzoyl, phenylacetyl, methoxycabonyl, ethoxycarbonyl, propoxycarbonyl, butoxycarbonyl, crotonoyl and methyl crotonoyl;
G.sub.3 and G can be connected to form a cyclic structure;
R.sup.7 is as defined hereinabove;
with the .beta.-lactams of the formula (V) ##STR18## wherein G is a hydroxyl protecting group selected from the group consisting of methoxylmethyl, methoxyethyl, 1-ethoxyethyl, benzyloxymethyl, (.beta.-trimethylsilylethoxyl)methyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, 2,2,2-trichloroethoxymethyl, trimethylsilyl, triethylsilyl, tripropylsilyl, dimethylethylsilyl, dimethyl(t-butyl)silyl, diethylmethylsilyl, dimethylphenylsilyl, diphenylmethylsilyl, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl and trifluoroacetyl;
and R.sup.1 and R.sup.2 are as defined above; and
(b) deprotecting of said hydroxyl protecting groups.

### Claim 13 (depends on 12)

The process according to claim 12 wherein said base is selected from the group consisting of sodium hexamethyldisilazide, potassium hexamethyldisilazide, lithium hexamethyldisilazide, sodium diisopropylamide, potassium diisopropylamide, lithium diisopropylamide, sodium hydride, potassium hydride, lithium hydride, calcium hydride, magnesium hydride, phenyllithium, methyllithium, and butyllithium.

### Claim 14 (depends on 13)

The process according to claim 13 wherein R.sup.1, R.sup.2, and R are independently a straight chain or branched alkyl radical having 1 to 10 carbon atoms, a straight chain or branched alkenyl radical having 2 to 10 carbon atoms, or a straight chain or branched alkynyl radical having 2 to 10 carbon atoms, a cycloalkyl radical having 3 to 10 carbon atoms, a heterocycloalkyl radical having 3 to 10 carbon atoms, a cycloalkenyl radical having 3 to 10 carbon atoms, a heterocycloalkenyl radical having 3 to 10 carbon atoms, a polycycloalkyl radical having 6 to 20 carbon atoms, an aryl radical having 6 to 20 carbons, a heteroaryl radical having 3 to 15 carbon atoms;
or R.sup.2 is RO--, RS-- or RR'N radical wherein R is as defined above,
R' is a hydrogen or R as defined above; R and R' can be connected to form a cyclic structure which has 2 to 10 carbon atoms;
R.sup.3, R.sup.4, R.sup.5, or R.sup.6 is a hydrogen or an acyl radical having 1 to 20 carbons or R as defined above or a hydroxyl protecting group; wherein said radicals of R.sup.1, R.sup.2 and R are each substituted with at least one halogen, hydroxyl, amino, mercapto, cyano, carboxyl group; alkoxy, alkylamino, dialkylamino, alkylthio, alkoxycarboxyl group wherein said alkyl portion has 1 to 15 carbon atoms; aryloxy, arylthio, aryloxycarbonyl, wherein said aryl portion has 6 to 20 carbon atoms; or heteroarylthio, heteroaryloxy carbonyl wherein said heteroaryl portion has 3 to 15 carbon atoms.

### Claim 15 (depends on 13)

A process according to the claim 13 wherein R.sup.1 is an alkyl radical selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, heptyl, isoheptyl, octyl, isooctyl, cyclohexylmethyl, cyclohexylethyl, benzyl, phenylethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and adamantyl, or an alkenyl radical selected from the group consisting of vinyl, allyl, 2-phenylethenyl, 2-furylethenyl, 2-pyrrolylethenyl, 2-pyridylethenyl, 2-thienylethyl, or an unsubstituted or substituted alkynyl radical selected from the group consisting of ethynyl and propargyl or an aryl radical selected from the group consisting of phenyl, tolyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 4-chlorophenyl, and naphthyl; or a heteroaryl radical selected from the group consisting of furyl, pyrrolyl, and pyridyl, or a cycloalkenyl radical selected from the group consisting of cyclopentenyl, cyclohexenyl and cycloheptenyl or a heterocycloalkyl selected from the group consisting of oxiranyl, pyrrolidinyl, piperidinyl, tetrahydrofuryl, and tetrahydropyranyl, or a heterocycloalkenyl radical selected from the group consisting of dihydrofuryl, dihydropyrrolyl, dihydropiranyl, and dihydropyridyl;
R.sup.2 is an unsubstituted or substituted alkyl, alkenyl, alkynyl, aryl or heteroaryl radical selected from the group consisting of phenyl, tolyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isopropyl, isobutyl, neopentyl, hexyl, heptyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, phenylethenyl, crotyl, allyl, vinyl, propargyl, pyridinyl, furyl, thienyl, pyrrolidinyl, and piperidinyl;
or R.sup.2 is RO--, RS--, or RR'N-- wherein R is an unsubstituted or substituted alkyl radical selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, heptyl, isoheptyl, octyl, isooctyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and adamantyl, or an alkenyl radical selected from the group consisting of vinyl and allyl, or an aryl radical selected from phenyl and naphthyl, or a heteroaryl radical selected from the group consisting of furyl, pyrrolyl, and pyridyl, or a cycloalkenyl radical selected from the group consisting of cyclopentenyl, cyclohexenyl and cycloheptenyl, or a heterocycloalkyl radical selected from the group consisting of an oxiranyl, tetrahydrofuryl, pyrrolidinyl, piperidinyl, and tetrahydropiranyl, or a heterocycloalkenyl radical selected from the group consisting of dihydrofuryl, dihydropyrrolyl, dihydropiranyl, dihydropyridyl; R' is a hydrogen or R as defined above; cyclic RR'N-- is a radical including an aziridino, azetidino, pyrrolidino, piperidino or morpholino group;
R.sup.3 is a hydrogen or an acyl or an alkyl or an alkenyl or an alkynyl or an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, or an unsubstituted or substituted aryl or heteroaryl radical or a hydroxyl protecting group;
R.sup.4 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.6 is a hydrogen or an acyl radical or an alkyl, alkenyl or alkynyl radical, an unsubstituted or substituted cycloalkyl, heterocycloalkyl, cycloalkenyl or heterocycloalkenyl radical, an unsubstituted or substituted aryl or heteroaryl radical, or a hydroxyl protecting group;
R.sup.5 and R.sup.6 can be connected to form a cyclic structure;
R.sup.7 is an acyl group;
R.sup.8 is an hydrogen or a hydroxyl protecting group;
wherein said hydroxyl protecting group is selected from the group consisting of methoxylmethyl, methoxyethyl, 1-ethoxyethyl, benzyloxymethyl, (.beta.-trimethylsilylethoxyl)methyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, 2,2,2-trichloroethoxymethyl, trimethylsilyl, triethylsilyl, tripropylsilyl, dimethylethylsilyl, dimethyl(t-butyl)silyl, diethylmethylsilyl, dimethylphenylsilyl and diphenylmethylsilyl, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl and trifluoroacetyl; and
R.sup.5 and R.sup.6 form a cyclic structure with two oxygen atoms of the skeleton of said taxane, wherein said cyclic structure is selected from the group consisting of carbonate, methylacetal, ethylacetal, propylacetal, butylacetal, phenylacetal, dimethylketal, diethylketal, dipropylketal and dibutylketal.

### Claim 16 (depends on 13)

A process according to the claim 13 wherein R.sup.1 is a phenyl, tolyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluorophenyl, 4-trifluoromethylphenyl, 4-hydroxyphenyl, 1-naphthyl, 2-naphthyl, pyridyl, furyl, thienyl, pyrrolyl, N-methylpyrrolyl, 2-phenylethenyl, 2-furylethenyl, 2-pyridylethenyl, 2-thienylethenyl, 2-phenylethyl, 2-cyclohexylethyl, cyclohexylmethyl, isobutyl or cyclohexyl;
R.sup.2 is selected from the group consisting of phenyl, tolyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isopropyl, isobutyl, neopentyl, hexyl, heptyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, and phenylethenyl;
or R.sup.2 is RO-- wherein R is selected from the group consisting of a methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, cyclohexyl, phenyl, benzyl and 9-fluorenylmethyl;
or R.sup.2 is RR'N-- selected from the group consisting of a methylamino, ethylamino, propylamino, isopropylamino, butylamino, isobutylamino, tert-butylamino, neopentylamino, cyclohexylamino, phenylamino or benzylamino, dimethylamino, diethylamino, dipropylamino, dibutylamino, dipentylamino, dihexylamino, dicyclohexylamino, methyl(tert-butyl)amino, cyclohexyl(methyl)amino, methyl(phenyl)amino, pyrrolidiono, piperidino, or morpholino group;
R.sup.3 and R.sup.4 are selected from the group consisting of a hydrogen, acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, and trifluoroacetyl, benzoyl, phenylacetyl, acryloyl, and crotyl, cinnamoyl, allyl, benzyl, methoxymethyl, methoxyethyl, 1-ethoxyethyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluroenylmethoxycarbonyl, trimethylsilyl, triethylsilyl, (tert-butyl)dimethylsilyl;
R.sup.5 is selected from the group consisting of a hydrogen, acetyl, chloroacetyl, allyl, benzyl, acryloyl, crotyl, and cinnamoyl and R.sup.6 is a hydrogen; wherein R.sup.5 and R.sup.e are connected to form a cyclic structure, and connected R.sup.5 -R.sup.6 are selected from the group consisting of carbonyl, propylidene, butylidene, pentylidene, phenylmethylidene, dimethylmethylidene, diethylmethylidene, dipropylmethylidene, dibutylmethylidene, methoxymethylidene, ethoxymethylidene, methylene, ethylene, and propylene;
R.sup.7 is selected from the group consisting of benzoyl and cyclohexanecarbonyl;
R.sup.8 is selected from the group consisting of a hydrogen, 1-ethoxyethyl, 2,2,2-trichloroethoxylcarbonyl, trimethylsilyl, triethylsilyl, and tert-butyldimethylsilyl;
G.sub.1 and G.sub.2 are selected from the group consisting of an acetyl, chloroacetyl, dichloroacetyl, trichloroacetyl, and trifluoroacetyl, benzoyl, phenylacetyl, acryloyl, and crotyl, cinnamoyl, allyl, benzyl, methoxymethyl, methoxyethyl, 1-ethoxyethyl, tetrahydropyranyl, 2,2,2-trichloroethoxylcarbonyl, benzyloxycarbonyl, tert-butoxycarbonyl, 9-fluorenylmethoxycarbonyl, trimethyl-silyl, triethylsilyl, (tert-butyl)dimethylsilyl;
G.sub.3 is selected from the group consisting of an acetyl, chloroacetyl, allyl, benzyl, acryloyl, crotyl, and cinnamoyl and G.sub.4 is a hydrogen;
or G.sub.3 and G.sub.4 are connected to form a cyclic structure, and connected G.sub.3 -G.sub.4 are selected from the group consisting of carbonyl, propylidene, butylidene, pentylidene, phenylmethylidene, dimethylmethylidene, diethylmethylidene, dipropyl-methylidene, dibutylmethylidene, methoxymethylidene, ethoxymethylidene, methylene, ethylene, and propylene;
G is selected from the group consisting of a 1-ethoxyethyl, 2,2,2-trichloroethoxylcarbonyl, trimethylsilyl, triethylsilyl, and tert-butyldimethylsilyl.

### Claim 17 (depends on 13)

A process according to the claim 13 wherein R.sup.1 is a phenyl, 4-methoxyphenyl, 3,4-dimethoxyphenyl, 4-fluoromethyl, 4-trifluoromethylphenyl, furyl, 2-phenylethenyl, 2-phenylethyl, 2-cyclohexylethyl, 2-furylethenyl, 2-phenylethyl, 2-cyclohexylethyl, cyclohexylmethyl or cyclohexyl;
R.sup.2 is selected from the group consisting of phenyl, tolyl, 4-methoxyphenyl, biphenyl, 1-naphthyl, 2-naphthyl, isobutyl, pentyl, neopentyl, hexyl, cyclohexyl, cyclohexylmethyl, benzyl, phenylethyl, and phenylethenyl;
or R.sup.1 is RO-- wherein R is selected from the group consisting of a methyl, ethyl, butyl, tert-butyl, cyclohexyl, phenyl, and benzyl;
or R.sup.2 is RR'N-- selected from the group consisting of an ethylamino, tert-butylamino, phenylamino, benzylamino, dimethylamino and morpholino group;
R.sup.3 is a hydrogen, triethylsilyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.4 is a hydrogen, acetyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.5 is an acetyl; R.sup.6 is a hydrogen; and
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is benzoyl or cyclohexanecarbonyl;
R.sup.8 is a hydrogen, 1-ethoxyethyl, triethylsilyl, or tert-butyldimethylsilyl;
G.sub.1 is a triethylsilyl or 2,2,2-trichloroethoxylcarbonyl;
G.sub.2 is an acetyl or 2,2,2-trichloroethoxylcarbonyl;
G.sub.3 is an acetyl and G.sub.4 is a hydrogen;
or G.sub.3 and G.sub.4 are connected to form a carbonate;
G is a 1-ethoxyethyl, triethylsilyl, or tert-butyldimethylsilyl;
said base is selected from the group consisting of sodium hexamethyldisilazide, potassium hexamethyldisilazide, lithium hexamethyldisilazide, sodium diisopropylamide, potassium diisopropylamide, lithium diisopropylamide, sodium hydride, potassium hydride, lithium hydride, phenyllithium, methyllithium, and butyllithium.

### Claim 18 (depends on 13)

A process according to the claim 13 wherein
R.sup.1 is a phenyl;
R.sup.2 is phenyl or tert-butoxy;
R.sup.3 is a hydrogen, triethylsilyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.4 is a hydrogen, acetyl or 2,2,2-trichloroethoxylcarbonyl;
R.sup.5 is an acetyl and R.sup.6 is a hydrogen;
or R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is benzoyl;
R.sup.8 is a hydrogen or 1-ethoxyethyl;
G.sub.1 is a triethylsilyl or 2,2,2-trichloroethoxylcarbonyl
G.sub.2 is an acetyl or 2,2,2-trichloroethoxylcarbonyl;
G.sub.3 is an acetyl and G.sub.4 is a hydrogen;
or G.sub.3 and G.sub.4 are connected to form a carbonate;
G is a 1-ethoxyethyl;
said base is sodium hexamethyldisilazide, potassium hexamethyldisilazide, lithium hexamethyldisilazide, or lithium diisopropylamide.

### Claim 19 (depends on 12)

A process according to claim 12 wherein
R.sup.1 is an isobutyl, isobutenyl, crotyl, or furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acyl, carbamoyl, N-alkylcarbamoyl, N,N-dialkylcarbamoyl, or alkoxycarbonyl radical;
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is an arylcarbonyl, alkylcarbonyl, or alkenylcarbonyl radical;
R.sup.8 is a hydrogen.

### Claim 20 (depends on 12)

The process according to claim 12 wherein
R.sup.1 is an isobutyl, isobutenyl, crotyl, furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acetyl, propanoyl, cyclopropanecarbonyl, N,N-dimethylcarbamoyl, or methoxycarbonyl;
R.sup.5 and R.sup.6 are connected to form a carbonate;
R.sup.7 is a benzoyl;
R.sup.8 is a hydrogen.

### Claim 21 (depends on 12)

The process according to claim 12 wherein
R.sup.1 is an isobutyl, isobutenyl, crotyl, furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acyl, carbamoyl, N-alkylcarbamoyl, N,N,-dialkylcarbamoyl, or alkoxycarbonyl radical;
R.sup.5 is a hydrogen;
R.sup.6 is a hydrogen;
R.sup.7 is a benzoyl;
R.sup.8 is a hydrogen.

### Claim 22 (depends on 12)

The process according to claim 12 wherein
R.sup.1 is an isobutyl, isobutenyl, crotyl, furyl;
R.sup.2 is a tert-butoxy;
R.sup.3 is a hydrogen;
R.sup.4 is a hydrogen, acetyl, propanoyl, cyclopropanecarbonyl, N,N-dimethylcarbamoyl, or methoxycarbonyl;
R .sup.5 is a hydrogen;
R .sup.6 is a hydrogen;
R .sup.7 is a benzoyl;
R .sup.8 is a hydrogen.

### Claim 23 (depends on 8)

A pharmaceutical composition having antineoplastic activity comprising the compound of claim 8 and a physiologically acceptable carrier therefor.

### Claim 24 (depends on 9)

A pharmaceutical composition having antineoplastic activity comprising the compound of claim 9 and a physiologically acceptable carrier therefor.

### Claim 25 (depends on 10)

A pharmaceutical composition having antineoplastic activity comprising the compound of claim 10 and a physiologically acceptable carrier therefor.

### Claim 26 (depends on 11)

A pharmaceutical composition having antineoplastic activity comprising the compound of claim 11 and a physiologically acceptable carrier therefor.

### Claim 27 (depends on 8)

A method of treating tumors selected from the group consisting of ovarian, breast, adriamycin resistant breast cancer, non-small cell lung and colon cancer which comprises administering to a patient an effective antitumor amount of the compound of claim 8.

### Claim 28 (depends on 9)

A method of treating tumors selected from the group consisting of ovarian, breast, adriamycin resistant breast cancer, non-small cell lung and colon cancer which comprises administering to a patient an effective antitumor amount of the compound of claim 9.

### Claim 29 (depends on 10)

A method of treating tumors selected from the group consisting of ovarian, breast, adriamycin resistant breast cancer, non-small cell lung and colon cancer which comprises administering to a patient an effective antitumor amount of the compound of claim 10.

### Claim 30 (depends on 11)

A method of treating tumors selected from the group consisting of ovarian, breast, adriamycin resistant breast cancer, non-small cell lung and colon cancer which comprises administering to a patient an effective antitumor amount of the compound of claim 11.