# US 5,705,496 A · Crystalline benzathine salt of cefonicid and its preparation

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- Number: US 5,705,496 A
- Document ID: US5705496A
- Status: Granted
- Kind: A
- Application number: 08/522,386
- Filed: 1995-09-25
- Granted: 1998-01-06
- Earliest claimed: 1995-09-25
- Assignees: SmithKline Beecham Corporation
- Inventors: Theodore John Polansky
- Web page: https://patentgrep.com/patent/US5705496A

## CPC

- A61K 31/546: containing further heterocyclic rings, e.g. cephalothin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to benzathine salts of cefonicid, a member of the cephalosporin family of antibiotics, which are crystalline. ##STR1##

## Claims

### Claim 1

N,N'-Dibenzylethylene diamine -7-›(hydroxyphenylacetyl)amino-8-oxo-3-›››1-(sulfomethyl)-1H-tetrazol-5-yl !thio!methyl!-5-thia-1-azabicyclo›4.2.0!oct-2-ene-2-carboxylate.

### Claim 2 (depends on 1)

The compound of claim 1 having a melting point of about 189.degree.-198.degree. C.

### Claim 3 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

### Claim 4 (depends on 1)

A pharmaceutical composition of claim 1 wherein such composition is a solid powder or crystalline composition.

### Claim 5 (depends on 1)

A method for treating bacterial infections comprising administering the compound of claim 1.

### Claim 6

A process for preparing the benzathine salt of cefonicid which comprises treating an aqueous solution or suspension of cefonicid with an organic solvent and N,N'-dibenzylethylenediamine.

### Claim 7 (depends on 6)

The process according to claim 6 wherein the aqueous solution is treated with acetone, ethyl acetate, methylethylketone, methyisobutylketone, methanol, ethanol, propanol or isopropanol.

### Claim 8 (depends on 6)

The process of claim 6 wherein the aqueous solution is between about pH 2 and 8.