# US 5,705,488 A · Injectable compositions for soft tissue augmentation

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- Number: US 5,705,488 A
- Document ID: US5705488A
- Status: Granted
- Kind: A
- Application number: 08/589,455
- Filed: 1996-01-22
- Granted: 1998-01-06
- Earliest claimed: 1993-09-07
- Assignees: Datascope Investment Corp.
- Inventors: Ernst Janzen; Matthias Johannes Hoekstra; Richard P. Dutrieux
- Web page: https://patentgrep.com/patent/US5705488A

## CPC

- A61L 27/3683: {subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment}
- A61K 38/39: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A61L 27/227: {Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24}
- A61L 27/26: Mixtures of macromolecular compounds
- A61L 27/3641: {characterised by the site of application in the body (materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60)}
- A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Injectable implant compositions for soft tissue augmentation comprise elastin and collagen and a biocompatible carrier. An injectable implant composition for soft tissue augmentation is derived from the ligamentum nuchae which has been treated to remove non-collagenous and non-elastinous proteins. Methods of making an injectable implant composition for soft tissue augmentation from the ligamentum nuchae are described.

## Claims

### Claim 1

A method of treating urinary incontinence comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier into the area of the urethral sphincter, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 2

A method of breast augmentation comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier into the breast, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 3

A method of cosmetic treatment of wrinkles comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier into the soft tissue in or around the face, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 4

A method of load bearing tissue augmentation comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier between said load bearing tissue and a load-exerting medium, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 5

A method of treating acne scars or viral pock marks comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier into the soft tissue underlying said scar or pock mark, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 6

A method of changing the contours of a nose comprising the step of injecting a composition derived from animal tissue, comprising elastin and collagen and a biocompatible carrier into the soft tissue of the nose, said tissue having been comminuted to break up the natural collagen/elastin matrix.

### Claim 7

A method of making an injectable implant composition derived from animal tissue, for soft tissue augmentation from ligamentum nuchae, said tissue having been comminuted to break up the natural collagen/elastin matrix, comprising the steps of
washing the ligamentum nuchae in water,
treating the washed ligamentum nuchae with a strong alkali solution,
treating the resulting ligamentum nuchae with an acid,
treating the acid-treated ligamentum nuchae with a base to neutralize the acid,
mechanically working the neutralized ligamentum nuchae to separate collagen and elastin fibers, and
suspending at least some of the collagen and elastin fibers in a suitable carrier.

### Claim 8

A method of making an injectable implant composition derived from animal tissue for soft tissue augmentation, said tissue having been comminuted to break up the natural collagen/elastin matrix, comprising the steps of
selecting tissue starting material from the group consisting of animal ligaments, tendons and membranes,
washing said tissue in water,
treating the washed tissue with a strong alkali solution,
treating the resulting tissue with an acid,
treating the acid-treated tissue with a base to neutralize the acid,
mechanically working the neutralized tissue to separate elastin fibers, and
suspending at least some of the elastin fibers in a suitable carrier.