Drug composition containing nucleic acid copolymer
AssigneeNippon Shinyaku Co., Ltd.
InventorsYano Junichi, Tadaaki Ohgi
Life of this patent
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Abstract
This invention has for its object to insure an effective utilization of single-stranded nucleic acid copolymers, particularly poly(adenylic acid-uridylic acid), and to provide a pharmaceutical composition having antitumor activity. The invention typically relates to a pharmaceutical composition comprising a lipid device such as Lipofectin (trademark), 3-O-(4-dimethylaminobutanoyl)-1,2-O-dioleylgycerol, 3-O-(2-dimethylamino-ethyl)carbamoyl-1,2-O-dioleylglycerol, 3-O-(2-diethylaminoethyl) carbamoyl-1,2-O-dioleylgycerol, or 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoylglycerol and poly(adenylic acid-uridylic acid).
Claims10
A composition comDrisinq a lipid device and a single-stranded nucleic acid copolymer, wherein said lipid device is a mixture of a phospholipid and a compound of the following general formula ##STR17## wherein R.sup.1 and R.sup.2 are not the same and each represents OY or --A--(CH.sub.2)n-E. n represents a whole number of 0-4. E represents pyrrolidino, piperidino, substituted or unsubstituted piperazino, morpholino, substituted or unsubstituted guanidino, or ##STR18## (R.sup.3 and R.sup.4 are the same or different and each represents hydrogen, lower(C.sub.1 -.sub.4) alkyl, hydroxy-lower(C.sub.1 -.sub.4) alkyl, or mono- or di-(lower) alkylaminoalkyl(C.sub.2-6)). A represents the following 1, 2, 3, 4, 5, 6, or 7 ##STR19## R and Y are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbon group of 10-30 carbon atoms or a saturated or unsaturated fatty acid residue of 10-30 carbon atoms.
A composition comprisinq a lipid and a single-stranded nucleic acid copolymer, wherein said lipid is a mixture of a phospholipid and a compound of the following general formula ##STR20## wherein R.sup.11 and R.sup.21 are the same or different and each represents oleyl or oleoyl. D represents --CH.sub.2 -- or --NH--. R.sup.30 and R.sup.40 are the same or different and each represents methyl or ethyl.
Dependencies are inferred from the claim text.