# US 5,705,186 A · Pharmaceutical composition for the systemic transdermal administration having the active substance morphine-6-glucuronide

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 5,705,186 A
- Document ID: US5705186A
- Status: Granted
- Kind: A
- Application number: 08/693,338
- Filed: 1996-10-09
- Granted: 1998-01-06
- Earliest claimed: 1994-02-07
- Assignees: LTS Lohmann Therapie-Systeme AG
- Inventors: Thomas Hille; Karlheinz Otto
- Web page: https://patentgrep.com/patent/US5705186A

## CPC

- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K 9/7023: {Transdermal patches and similar drug-containing composite devices, e.g. cataplasms (galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006)}
- A61K 9/7053: {obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene}
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A pharmaceutical composition for systemic transdermal administration containing morphine-6-glucuronide or a pharmaceutically acceptable acid addition salt thereof as the active agent.

## Claims

### Claim 1

In a transdermal therapeutic system in the form of a patch, the patch comprising an impermeable backing layer, a pressure sensitive adhesive polymer matrix reservoir layer, and an optional removable protective layer, the improvement wherein the matrix reservoir layer contains, as an active agent, an effective amount of morphine-6-glucuronide or a pharmaceutically applicable acid addition salt thereof.

### Claim 2 (depends on 1)

A system according to claim 1 wherein the active agent is the hydrochloride of morphine-6-glucuronide.

### Claim 3 (depends on 1)

A method for the treatment of pain which comprises applying to the skin of a patient in need of such treatment a transdermal therapeutic system as defined in claim 1.