# US 5,705,182 A · Additives to tampons > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,705,182 A - Document ID: US5705182A - Status: Granted - Kind: A - Application number: 08/470,852 - Filed: 1995-06-06 - Granted: 1998-01-06 - Earliest claimed: 1989-04-27 - Assignees: McNeil-PPC, Inc. - Inventors: Susan Kay Brown-Skrobot - Web page: https://patentgrep.com/patent/US5705182A ## CPC - A61L 15/20: containing organic materials - Y10S 604/904: Tampons - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ## Abstract Absorbent products, especially catamenial tampons, for absorbing body fluids, such as menstrual fluid, blood and wound exudates, comprise an amount of a compound effective to inhibit the production of toxic shock syndrome toxin-1 by Staphylococcus aureus bacteria when the products are brought into contact with the bacteria. The compound is selected from the group consisting of monoesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; diesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; and mixtures thereof. The monoesters and diesters have at least one hydroxyl group associated with their aliphatic alcohol residue. ## Claims ### Claim 1 A tampon comprising an absorbent material and a toxin-inhibiting amount of an active ingredient consisting essentially of a compound selected from the group consisting of: a) monoesters of a polyhydric aliphatic alcohol and a fatty acid containing from eight to eighteen carbon atoms and wherein said monoester has at least one hydroxyl group associated with its aliphatic alcohol residue; b) diesters of a polyhydric aliphatic alcohol and a fatty acid containing from eight to eighteen carbon atoms and wherein said diester has at least one hydroxyl group associated with its aliphatic alcohol residue; and c) mixtures of said monoesters and diesters, wherein said active ingredient is effective to inhibit the production of toxic shock syndrome toxin-1 by Staphylococcus aureus bacteria when said tampon is exposed to said bacteria. ### Claim 2 (depends on 1) A tampon according to claim 1 wherein said active ingredient is present in an amount which is at least about 0.1% based on the weight of said absorbent material. ### Claim 3 (depends on 1) A tampon according to claim 1 wherein said active ingredient is present in an amount which is at least about 0.5% based on the weight of said absorbent material. ### Claim 4 (depends on 1) A tampon according to claim 1 wherein said active ingredient is present in an amount which is at least about 1% based on the weight of said absorbent material. ### Claim 5 (depends on 1) A tampon according to claim 1 wherein said fatty acid is lauric acid. ### Claim 6 (depends on 1) A tampon according to claim 1 wherein said polyhydric alcohol is glycerol. ### Claim 7 (depends on 1) A tampon according to claim 1 wherein said compound is glyceryl monolaurate. ### Claim 8 (depends on 7) A tampon according to claim 7 wherein said glyceryl monolaurate is present in an amount which is at least 0.1% by weight based on the weight of said absorbent material. ### Claim 9 (depends on 7) A tampon according to claim 7 wherein said glyceryl monolaurate is present in an amount which is at least 0.5% by weight based on the weight of said absorbent material. ### Claim 10 (depends on 1) A tampon according to claim 1 wherein said compound comprises a mixture of glyceryl monolaurate and glyceryl dilaurate. ### Claim 11 (depends on 10) A tampon according to claim 10 wherein said mixture is present in an amount which is at least about 0.1% based on the weight of said absorbent material. ### Claim 12 (depends on 11) A tampon according to claim 11 wherein said mixture comprises at least 93% by weight of glyceryl monolaurate. ### Claim 13 (depends on 10) A tampon according to claim 10 wherein said mixture comprises at least about 95% by weight of glyceryl monolaurate. ### Claim 14 (depends on 10) A tampon according to claim 10 wherein said mixture is present in an amount which is at least about 0.5% by weight based on the weight of said absorbent material. ### Claim 15 (depends on 14) A tampon according to claim 14 wherein said mixture comprises at least about 93% by weight of glyceryl monolaurate. ### Claim 16 (depends on 14) A tampon according to claim 14 wherein said mixture comprises at least about 95% by weight of glyceryl monolaurate. ### Claim 17 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl monocaprylate. ### Claim 18 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl caprate. ### Claim 19 (depends on 1) A tampon according to claim 1 wherein said compound comprises a mixture of glyceryl monocaprylate and glyceryl caprate. ### Claim 20 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl monomyristate. ### Claim 21 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl monopalmitate. ### Claim 22 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl monostearate. ### Claim 23 (depends on 1) A tampon according to claim 1 wherein said compound comprises glyceryl monooleate.