# US 5,705,179 A · Tissue augmentation with perfluoropolyether compounds

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- Number: US 5,705,179 A
- Document ID: US5705179A
- Status: Granted
- Kind: A
- Application number: 08/195,189
- Filed: 1994-02-10
- Granted: 1998-01-06
- Earliest claimed: 1994-02-10
- Assignees: Vivante Internatinale, Inc.
- Inventors: James E. Fulton, Jr.
- Web page: https://patentgrep.com/patent/US5705179A

## CPC

- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Perfluoropolyether compounds are used for augmenting lost or damaged tissue. The perfluoropolyether compounds are subcutaneously administered in the form of micro-droplets to stimulate the formation of collagen at selected sites of tissue loss or damage in an individual in need thereof.

## Claims

### Claim 1

A method for augmenting tissue, said method comprising:
injecting an effective tissue-augmenting amount of a perfluoropolyether compound to an individual in need thereof at a site of tissue loss or damage, whereby the tissue lost or damaged at that site is augmented.

### Claim 2 (depends on 1)

The method of claim 1, wherein said perfluoropolyether compound is perfluoropolyethylisopropyl ether.

### Claim 3 (depends on 2)

The method of claim 2, wherein said perfluoropolyethylisopropyl ether has an average molecular weight of 1,500 or 3,200.

### Claim 4 (depends on 1)

The method of claim 1, wherein said perfluoropolyether compound is a perfluoropolyethylisopropyl ether having an average molecular weight of 6,250.

### Claim 5 (depends on 1)

The method of claim 1, wherein said perfluoropolyether compound is administered as a pharmaceutical composition, said composition including a pharmaceutically acceptable vehicle.

### Claim 6 (depends on 5)

The method of claim 5, wherein said pharmaceutical composition further comprises glycerin and sodium lauryl sulfate.

### Claim 7 (depends on 1)

The method of claim 1, wherein said perfluoropolyether compound is administered as microdroplets.

### Claim 8 (depends on 1)

The method of claim 1, wherein said injection is subcutaneous injection.

### Claim 9

In combination, a syringe and perfluoropolyether compound for augmenting tissue, said syringe containing the perfluoropolyether compound.

### Claim 10 (depends on 9)

The combination of claim 9, wherein said syringe includes a cartridge containing the perfluoropolyethor compound.

### Claim 11 (depends on 10)

The combination of claim 10, wherein said cartridge contains about 0.2 ml to about 0.5 ml of said perfluoropolyether compound.

### Claim 12 (depends on 9)

The combination of claim 9, wherein said syringe further includes a needle, said needle having a gauge of between about 27 and 30.

### Claim 13 (depends on 9)

The combination of claim 9, wherein said perfluoropolyether compound is a perfluropolyethylisopropyl ether.

### Claim 14 (depends on 13)

The combination of claim 13, wherein said perfluropolyethylisopropyl ether has an average molecular weight of 1,500 or 3,200.

### Claim 15 (depends on 9)

The combination of claim 9, wherein said perfluoropolyether compound is a perfluoropolyethylisopropyl ether having an average molecular weight of 6,250.

### Claim 16 (depends on 9)

The combination of claim 9, wherein said combination further includes glycerin, polypropylene glycol or sodium lauryl sulfate.

### Claim 17 (depends on 9)

The combination of claim 9, wherein said combination further includes an additive selected from the group consisting of a steroid, antioxidant, preservative and emulsifier.

### Claim 18 (depends on 10)

The combination of claim 10, wherein said cartridge has a side wall, said side wall having a thickness of about 2 mm.