# US 5,705,168 A · Enhanced permeation of alpha-hydroxy acid enantiomer

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- Number: US 5,705,168 A
- Document ID: US5705168A
- Status: Granted
- Kind: A
- Application number: 08/452,444
- Filed: 1995-05-26
- Granted: 1998-01-06
- Earliest claimed: 1994-03-22
- Assignees: Bristol-Myers Squibb Company
- Inventors: Prakash Parab
- Web page: https://patentgrep.com/patent/US5705168A

## CPC

- A61K 31/205: Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61P 17/00: Drugs for dermatological disorders
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods of increasing the rate of lactic acid permeation in skin for the treatment of dermatological disorders by applying a composition containing an inorganic or organic salt of lactic acid in a dermatologically acceptable composition wherein at least 70% of the lactic acid moiety in the salt is L-lactic acid, and compositions for practicing such methods.

## Claims

### Claim 1

A dermatological composition comprising an inorganic or organic lactate in a dermatologically acceptable carrier, from about 70% to about 100% of the lactate being an L-lactate salt.

### Claim 2 (depends on 1)

The composition as claimed in claim 1 wherein the lactate is an organic lactate.

### Claim 3 (depends on 2)

The composition as claimed in claim 2 wherein the lactate is a lactate of an amino acid.

### Claim 4 (depends on 3)

The composition as claimed in claim 3 wherein the amino acid is selected from the group consisting of lysine and histidine.

### Claim 5 (depends on 1, 2, 3, 4)

The composition as claimed in claim 1, 2, 3 or 4 wherein the composition has a pH of 2.5 to 9.

### Claim 6 (depends on 1, 2, 3, 4)

The composition as claimed in claim 1, 2, 3 or 4 wherein at least about 85% of the lactate is the L-lactic anion.

### Claim 7 (depends on 1, 2, 3, 4)

The composition as claimed in claim 1, 2, 3 or 4 wherein the composition has a pH of from about 3.5 to 7 and at least about 85% of the lactate is the L-lactic anion.

### Claim 8 (depends on 1)

The composition as claimed in claim 1 wherein lactate is an inorganic lactate.

### Claim 9 (depends on 8)

The composition as claimed in claim 8 wherein the lactate is selected from the group consisting of ammonium, sodium and potassium lactates.

### Claim 10 (depends on 8, 9)

The composition as claimed in claim 8 or 9 wherein the composition has a pH of from 2.5 to 9.

### Claim 11 (depends on 8, 9)

The composition as claimed in claim 8 or 9 wherein at least about 85% of the lactate is the L-lactic anion.

### Claim 12 (depends on 8, 9)

The composition as claimed in claim 8 or 9 wherein the composition has a pH of from about 3.5 to 7 and at least about 85% of the lactate is the L-lactic anion.