# US 5,705,144 A · Cosmetic composition containing retinol and dioic acid

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- Number: US 5,705,144 A
- Document ID: US5705144A
- Status: Granted
- Kind: A
- Application number: 08/614,942
- Filed: 1996-03-11
- Granted: 1998-01-06
- Earliest claimed: 1992-09-30
- Assignees: Unilever Patent Holdings B.V.
- Inventors: Clive Roderick Harding; Caroline Marian Lee; Ian Richard Scott
- Web page: https://patentgrep.com/patent/US5705144A

## CPC

- A61K 8/671: {Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal}
- A61K 8/362: Polycarboxylic acids
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/004: {Aftersun preparations}
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

A composition for topical application to human skin in order to promote the repair of photo-damaged skin and/or to reduce or prevent the damaging effects of ultra-violet light on skin and/or to lighten the skin comprising retinol or a derivative thereof and a dioic acid.

## Claims

### Claim 1

A composition suitable for topical application to human skin in order to promote skin lightening, repair of photo-damaged skin and to reduce or prevent the damaging effects of ultra-violet light on skin, which composition comprises a synergistically effective mixture of:
i) an effective amount of from 0.01 to 10% by weight of retinol or a derivative thereof having the structure (1): ##STR6## where X represents H or --COR.sup.1 R.sup.1 represents a group chosen from branched or unbranched, alkyl or alkenyl groups having an average of from 1 to 20 carbon atoms; and
ii) an effective amount of from 0.1 to 30% by weight of a dioic acid having the general structure (2)
COOH--(C.sub.a H.sub.b)--COOH (2)
where a is an integer of from 6 to 20 and b is an integer of from 8 to 40.

### Claim 2 (depends on 1)

A composition according to claim 1 wherein the amount of retinol or a derivative thereof having the structure (1) is from 0.05 to 5% by weight of the composition.

### Claim 3 (depends on 1)

A composition according to claim 1 wherein the amount of retinol or a derivative thereof having the structure (1) is from 0.05 to 1% by weight of the composition.

### Claim 4 (depends on 1)

A composition according to claim 1 wherein the amount of dioic acid is from 1 to 25% by weight of the composition.

### Claim 5 (depends on 1)

A composition according to claim 1 wherein the amount of dioic acid is from 5 to 20% by weight of the composition.

### Claim 6 (depends on 1)

A composition according to claim 1 wherein the dioic acid is selected from the group consisting of C.sub.9 to C.sub.18 saturated, mono- and di-unsaturated dioic acids and mixtures thereof.

### Claim 7 (depends on 1)

A composition according to claim 1 wherein the composition comprises trans-retinol.

### Claim 8 (depends on 1)

A method for promoting skin lightening, repairing photo-damaged skin and for reducing or preventing the damage to skin due to exposure to ultra-violet light which comprises topically applying an effective amount of the composition of claim 1 to the skin which is damaged or subject to such damage by exposure to ultra-violet light.

### Claim 9 (depends on 1)

A composition according to claim 1 including a 1-25% by weight of the composition, of a mixture of water-dispersible and oil-dispersible ultrafine titanium dioxide particles.