# US 5,703,261 A · Process for the production of sulfuric acid semi-esters

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- Number: US 5,703,261 A
- Document ID: US5703261A
- Status: Granted
- Kind: A
- Application number: 08/624,591
- Filed: 1996-07-10
- Granted: 1997-12-30
- Earliest claimed: 1993-10-09
- Assignees: Schering Corporation
- Inventors: Klaus Junghans
- Web page: https://patentgrep.com/patent/US5703261A

## CPC

- C07J 31/006: {not covered by C07J31/003}
- C07J: STEROIDS (seco-steroids C07C)

## Abstract

The invention relates to a process for the production of sulfuric acid semi-esters of general formula I RO--SO.sub.2 --OH (I), in which R represents an organic radical, from hydroxy compounds of general formula II R--OH (II), in which R has the same meaning as in formula I, characterized in that the latter is reacted in an inert solvent with a disulfuric acid salt of general formula III O(SO.sub.2 OX).sub.2 (III), in which X symbolizes an alkali metal atom.

## Claims

### Claim 1

Process for the production of sulfuric acid semi-esters of general formula I
RO--SO.sub.2 --OH (I),
in which
R represents an organic radical, from hydroxy compounds of general formula II
R--OH (II),
in which
R has the same meaning as in formula I, characterized in that the latter is reacted in an inert solvent with a disulfuric acid salt of general formula III
O(SO.sub.2 OX).sub.2 (III),
in which
X symbolizes an alkali metal atom.

### Claim 2 (depends on 1)

Process for the production of sulfuric acid semi-esters of general formula I according to claim 1, wherein R symbolizes the radical of a hydroxy steroid.

### Claim 3

Process for the production of conjugated estrogens of general formula Ia ##STR3## in which the three bonds characterized by . . . . . . symbolize three single bonds, two single bonds and a double bond, or two conjugated double bonds, and
Y represents a carbonyl group, a hydroxymethylene group, an acyloxymethylene group with up to 8 carbon atoms in the acyl radical or a benzyloxymethylene group, wherein hydroxy steroids of general formula IIa ##STR4## in which bonds . . . . . . . and Y have the same meanings as in formula Ia, are reacted in an inert solvent with a disulfuric acid salt of general formula III
O(SO.sub.2 OX).sub.2 (III),
in which
X symbolizes an alkali metal atom.