# US 5,703,205 A · Laminin a chain polypeptides from the amino terminal golbular domain

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- Number: US 5,703,205 A
- Document ID: US5703205A
- Status: Granted
- Kind: A
- Application number: 08/072,283
- Filed: 1993-06-07
- Granted: 1997-12-30
- Earliest claimed: 1991-01-25
- Assignees: Regents of the University of Minnesota
- Inventors: Amy P. N. Skubitz; Leo T. Furcht
- Web page: https://patentgrep.com/patent/US5703205A

## CPC

- C12N 5/0068: {General culture methods using substrates (for specific animal cell type C12N5/06)}
- A61L 27/34: Macromolecular materials
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 14/78: Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C12N 2533/52: Fibronectin; Laminin
- Y10S 977/738: Modified with biological, organic, or hydrocarbon material
- Y10S 977/813: Of specified inorganic semiconductor composition, e.g. periodic table group IV-VI compositions
- Y10S 977/895: having step or means utilizing chemical property
- Y10S 977/902: Specified use of nanostructure
- Y10S 977/915: Therapeutic or pharmaceutical composition
- Y10S 977/923: Cell culture
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Polypeptides derived from domain VI of the amino terminal globule of the A chain of laminin and having sequences of at least about 5 amino acids, and which exhibit cell adhesion and cell spreading capacity are described. Medical devices such as prosthetic implants, per-cutaneous devices and cell culture substrates coated with a composition including the described polypeptides are also provided.

## Claims

### Claim 1

A laminin polypeptide fragment having a sequence of at least five amino acids corresponding substantially to an amino acid sequence from residues 1-158 or residues 204-251 within domain VI of the A chain of laminin, wherein said polypeptide promotes cell adhesion.