Process for removing bile salts from a patient and compositions therefor
AssigneeGelTex Pharmaceuticals, Inc.
InventorsW. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Abstract
A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group: M is ##STR2## Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group.
Claims23
A method of synthesizing a crosslinked polymer having hydrophilic and hydrophobic units comprising:
- polymerizing a mixture comprising a hydrophilic vinylic monomer, a monoreactive hydrophobic vinylic co-monomer and a multifunctional crosslinking co-monomer in an alcoholic solvent under conditions suitable for free radical polymerization.
A method of synthesizing a crosslinked polymer having hydrophilic and hydrophobic units comprising:
- polymerizing a mixture comprising a hydrophilic vinylic monomer, a monoreactive hydrophobic vinylic co-monomer and a multifunctional crosslinking co-monomer in an alcoholic solvent, under conditions suitable for free radical polymerization wherein said hydrophilic vinylic monomer has a repeat unit having the formula ##STR32## where R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group;
- L is --NH-- or ##STR33## G is ##STR34## and each R.sup.2, R.sup.3, independently, is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group.
A method of synthesizing a crosslinked polymer having hydrophilic and hydrophobic units comprising:
- polymerizing a mixture comprising hydrophilic vinylic monomers, monoreactive hydrophobic vinylic co-monomers and a multifunctional crosslinking co-monomer in an alcoholic solvent, under conditions suitable for free radical polymerization wherein the alcoholic solvent is 2-propanol.
Dependencies are inferred from the claim text.