# US 5,703,128 A · Anti-osteopathic composition

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- Number: US 5,703,128 A
- Document ID: US5703128A
- Status: Granted
- Kind: A
- Application number: 08/613,265
- Filed: 1996-03-08
- Granted: 1997-12-30
- Earliest claimed: 1993-04-05
- Assignees: Hoechst Japan Limited; Koichi Shudo
- Inventors: Koichi Shudo; Tatsuo Sugioka; Mizuho Inazu; Hideyuki Tanaka; Tsutomu Inoue; Kazuyuki Kitamura
- Web page: https://patentgrep.com/patent/US5703128A

## CPC

- A61K 31/655: Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/195: having an amino group
- A61K 31/196: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A61K 31/336: having three-membered rings, e.g. oxirane, fumagillin
- A61K 31/35: having six-membered rings with one oxygen as the only ring hetero atom
- A61K 31/352: condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)}
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.

## Claims

### Claim 1

An anti-osteopathic composition for the treatment of a bone disease, said anti-osteopathic composition comprising as an active ingredient a compound or a pharmaceutically acceptable salt of a compound selected from:
4-›(3-isopropyl-4-isopropoxy-phenyl) carboxamide!benzoic acid (Am 685) or
3-hydroxy-4-›(3-isopropyl-4-isopropoxyphenyl) carboxamide!benzoic acid (Am 689).

### Claim 2

A compound selected from
4-›(3-isopropyl-4-isopropoxyphenyl)carboxamide!benzoic acid (Am685) or
3-hydroxy-4-›(3-isopropyl-4-isopropoxyphenyl)carboxamide!-benzoic acid (Am689).