# US 5,703,105 A · Stable, solid form antimicrobial compositions comprising 3-isothiazolones

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- Number: US 5,703,105 A
- Document ID: US5703105A
- Status: Granted
- Kind: A
- Application number: 07/784,852
- Filed: 1991-10-30
- Granted: 1997-12-30
- Earliest claimed: 1990-12-10
- Assignees: Rohm and Haas Company
- Inventors: George Harvey Redlich; Gary Lewis Willingham; John Steven Chapman
- Web page: https://patentgrep.com/patent/US5703105A

## CPC

- A01N 43/80: five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

Solid, stable forms of 3-isothiazolone microbicidal compositions and articles using a carrier which functions to stabilize the microbicide against chemical decomposition at room temperature and at applications temperature.

## Claims

### Claim 1

Antimicrobial composition comprising (A) a 3-isothiazolone compound, and (B) a water soluble polymeric carrier which is solid at room temperature, said carrier functioning to stabilize said 3-isothiazolone against chemical decomposition at room temperature and at applications temperature, said composition being solid at room temperature.

### Claim 2 (depends on 1)

Composition according to claim 1 wherein said 3-isothiazolone is of the formula ##STR2## wherein Y is selected from the group consisting of hydrogen; alkyl or substituted alkyl of 1 to 18 carbon atoms; unsubstituted or halogen-substituted alkenyl or alkynyl of 2 to 8 carbon atoms; cycloalkyl or substituted cycloalkyl of 3 to 12 carbon atoms; aralkyl or halogen-, lower alkyl-, or lower alkoxy-substituted aralkyl of up to 10 carbon atoms; and aryl, halogen-, lower alkyl-, or lower alkoxy-substituted aryl of up to 10 carbon atoms; and
X and X.sup.1 are independently selected from the group consisting of hydrogen, halogen, and (C.sub.1 -C.sub.4)alkyl.

### Claim 3 (depends on 1)

Composition according to claim 1 in the form of a powder, bar, pellet, tablet, cast sheet or granules.

### Claim 4 (depends on 1)

Composition according to claim 1 wherein said carrier is selected from the group consisting of polysaccharide polymers, cellulose polymers, derivatized cellulose polymers, polymers and copolymers of ethylene oxide and propylene oxide, polyurethane polymers having alternating hydrophobic and hydrophilic moieties, poly(maleic anhydride/methyl vinyl ether), polymethacrylic acid, and naphthalene formaldehyde concentrates.

### Claim 5 (depends on 1)

Composition according to claim 1 wherein the ratio of (A) to (B) is from about 0.1:99.9 to about 90:10 by weight.

### Claim 6 (depends on 5)

Composition according to claim 5 wherein said ratio is from about 1.5:98.5 to about 25:75.

### Claim 7 (depends on 1)

Composition according to claim 1 free of the presence of salt or stabilizer other than said carrier.

### Claim 8 (depends on 1)

Composition according to claim 1 wherein said composition is stable at room temperature for at least 3 days at 55.degree. C. as measured by retention of 3-isothiazolone compound.

### Claim 9 (depends on 1)

Article comprising a composition according to claim 1 in the form of a powder, bar, pellet, tablet, cast sheet, or granules.

### Claim 10 (depends on 8)

Method of delivering 3-isothiazolone antimicrobial compound to a locus for control of microbes comprising introducing a composition according to claim 8 onto or into said locus.