# US 5,703,091 A · N-substituted azabicycloalkane derivatives, their preparation and use

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- Number: US 5,703,091 A
- Document ID: US5703091A
- Status: Granted
- Kind: A
- Application number: 08/656,240
- Filed: 1996-06-06
- Granted: 1997-12-30
- Earliest claimed: 1993-12-04
- Assignees: BASF SE
- Inventors: Gerd Steiner; Rainer Munschauer; Liliane Unger; Hans-Jurgen Teschendorf; Thomas Hoger
- Web page: https://patentgrep.com/patent/US5703091A

## CPC

- C07D 487/04: Ortho-condensed systems
- A61P 21/02: Muscle relaxants, e.g. for tetanus or cramps
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/24: Antidepressants
- A61P 25/26: Psychostimulants, e.g. nicotine, cocaine
- C07D 497/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of the formula I ##STR1## where B, R.sup.1, R.sup.2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

## Claims

### Claim 1

An N-substituted 3-azabicycloalkane derivative of the formula I ##STR5## where B is a 3-, 5- or 6-membered ring which can contain 1 nitrogen atom and/or 1 oxygen atom and possibly one double bond,
R.sup.1 is a phenyl group which is unsubstituted or mono- or disubstituted by halogen atoms or C.sub.1 -C.sub.4 -alkyl, trifluoromethyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups,
R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 -alkyl radical,
n is the number 2, 3 or 4,
A is a hydrogen atom or one of the radicals
--CO--R.sup.5 or --NR.sup.6 --CO--R.sup.7,
R.sup.5 is a phenyl group which is unsubstituted or mono- or disubstituted by fluorine, chlorine, bromine or a hydroxyl, nitro, amino, C.sub.1-4 -alkanoylamino, C.sub.1-4 -alkylamino, C.sub.1 -C.sub.4 -alkyl or methoxy group or a naphthyl group which is unsubstituted or substituted by fluorine or chlorine,
R.sup.6 is a hydrogen atom or a methyl group, and
R.sup.7 is a phenyl group which is mono- or disubstituted by fluorine, chlorine, bromine, C.sub.1 -C.sub.4 -alkyl, hydroxyl or methoxy or monosubstituted by nitro, cyano, trifluoromethyl, amino, C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino or a thienyl, naphthyl, benzothienyl or indenyl group which is unsubstituted or substituted by fluorine, chlorine or nitro,
and their salts with physiologically tolerable acids.

### Claim 2 (depends on 1)

The compound of claim 1, wherein
B is a 5- or 6-membered ring which can contain one double bond,
R.sup.1 is a phenyl group which is unsubstituted or monosubstituted by halogen atoms,
R.sup.2 is hydrogen,
n is 2, and
A is --NH--CO--N-phenyl.

### Claim 3 (depends on 1)

A method of treating nervous disorders in a patient in need thereof which comprises: administering to the patient an effective amount of a compound of the formula I as defined in claim 1.