# US 5,703,082 A · Enantiomers of 1-›(4-chlorophenyl)phenylmethyl!-›(4-methylphenyl)sulfonyl!p i

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- Number: US 5,703,082 A
- Document ID: US5703082A
- Status: Granted
- Kind: A
- Application number: 08/460,844
- Filed: 1995-06-05
- Granted: 1997-12-30
- Earliest claimed: 1993-03-15
- Assignees: U C B S.A.
- Inventors: Eric Cossement; Guy Bodson; Jean Gobert
- Web page: https://patentgrep.com/patent/US5703082A

## CPC

- A61K 31/495: having six-membered rings with two {or more} nitrogen atoms as the only ring heteroatoms, e.g. piperazine {or tetrazines}(A61K31/48 takes precedence {; with three nitrogen atoms A61K31/53})
- A61P 11/06: Antiasthmatics
- A61P 17/00: Drugs for dermatological disorders
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/22: Anxiolytics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 295/073: with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D 295/088: to an acyclic saturated chain
- C07D 295/26: Sulfur atoms
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Levorotatory and dextrorotatory enantiomers of 1-›(4-chlorophenyl)phenylmethyl!-4-›(4-methylphenyl)sulfonyl!piperazine of the formula ##STR1## their preparation and use for the preparation of substantially optically pure enantiomers of 1-›(4-chlorophenyl)phenylmethyl!piperazine, which are themselves valuable intermediate products for the preparation of optically active therapeutic compounds having a very high degree of optical purity.

## Claims

### Claim 1

A method for achieving a tranquilizing or anxiolytic effect in a patient in need thereof, which comprises administering to said patient an effective amount of the dextrorotatory dihydrochloride of 2-›2-›4-›(4-chlorophenyl)phenylmethyl!-1-piperazinyl!ethoxy!ethanol.