# US 5,703,070 A · Indole, indazole and benzisoxazole compounds

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- Number: US 5,703,070 A
- Document ID: US5703070A
- Status: Granted
- Kind: A
- Application number: 08/663,464
- Filed: 1996-06-06
- Granted: 1997-12-30
- Earliest claimed: 1995-06-07
- Assignees: Adir et Compagnie
- Inventors: Gilbert Lavielle; Olivier Muller; Mark Millan; Valerie Audinot
- Web page: https://patentgrep.com/patent/US5703070A

## CPC

- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 413/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compound of formula (I): ##STR1## in which: R.sub.1 represents hydrogen, halogen, alkyl, alkoxy, trihalomethyl or hydroxyl, R.sub.2 represents hydrogen, alkyl or phenyl which is optionally substituted, ##STR2## or alternatively ##STR3## represents --O--N.dbd., 1.ltoreq.n.ltoreq.6, ##STR4## represents any one of the groups defined in the description, its isomers and its addition salts with a pharmaceutically acceptable acid or base, a medicinal products containing the same are useful in the treatment of schizophrenia.

## Claims

### Claim 1

A compound selected from the group having formula (I): ##STR16## in which: R.sub.1 represents hydrogen, halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, trihalomethyl, or hydroxyl,
R.sub.2 represents hydrogen or linear or branched (C.sub.1 -C.sub.6)alkyl or a phenyl group which is unsubstituted or substituted by halogen, alkyl, alkoxy, hydroxyl, or trihalomethyl, ##STR17## or represents --O--N.dbd., n is 1, 2, 3, 4, 5, or 6 ##STR18## represents any one of the following groups: ##STR19## in which: R represents hydrogen, halogen, linear or branched (C.sub.1 -C.sub.6)alkyl, linear or branched (C.sub.1 -C.sub.6)alkoxy, hydroxyl, or trihalomethyl,
Z represents oxygen, sulfur, or --NH--,
its isomers and its addition salts with a pharmaceutically-acceptable acid or base.

### Claim 2 (depends on 1)

A compound of claim 1, wherein ##STR20##

### Claim 3 (depends on 1)

A compound of claim 1, wherein n is equal to 2.

### Claim 4 (depends on 1)

A compound of claim 1, wherein n is equal to 3.

### Claim 5 (depends on 1)

A compound of claim 1, wherein ##STR21##

### Claim 6 (depends on 1)

A compound of claim 1, wherein ##STR22##

### Claim 7 (depends on 1)

A compound of claim 1, wherein ##STR23##

### Claim 8 (depends on 1)

A method for treating a living animal body afflicted with a schizophrenic condition comprising the step of administering to the living animal body an amount of a compound of claim 1 which is effective for alleviation of said condition.

### Claim 9 (depends on 1)

A pharmaceutical composition useful in treating schizophrenia comprising as active principle an effective amount of a compound of claim 1, together with one or more pharmaceutically-acceptable excipients or vehicles.