# US 5,703,041 A · Stable composition containing a water-sensitive cosmetic and/or dermatological active agent > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,703,041 A - Document ID: US5703041A - Status: Granted - Kind: A - Application number: 08/685,845 - Filed: 1996-07-24 - Granted: 1997-12-30 - Earliest claimed: 1995-07-25 - Assignees: L'oreal - Inventors: Isabelle Afriat; Didier Gagnebien - Web page: https://patentgrep.com/patent/US5703041A ## CPC - A61K 8/894: modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol - A61K 8/20: Halogens; Compounds thereof - A61K 8/23: Sulfur; Selenium; Tellurium; Compounds thereof - A61K 8/345: {containing more than one hydroxy group} - A61K 8/585: {Organosilicon compounds} - A61K 8/66: Enzymes - A61K 8/732: {Starch; Amylose; Amylopectin; Derivatives thereof} - A61K 8/88: Polyamides - A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone - A61K 8/92: Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof - A61Q 5/02: Preparations for cleaning the hair - A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings - A61Q 19/10: Washing or bathing preparations - A61K 2800/52: Stabilizers - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract A composition for topical application is provided which contains at least one water-sensitive active agent with a topical action and at least one polyol, the latter being present in a quantity which is effective for obtaining a water activity value of the composition of less than or equal to 0.85 with the aim of stabilizing the water-sensitive active agent, the composition containing at least one structuring agent chosen from polymers and oils. The water-sensitive active agent can, in particular, be an enzyme. The composition obtained can be used for cleansing and/or caring for and/or protecting the skin and/or keratinous fibers. ## Claims ### Claim 1 A composition comprising water, at least one water-sensitive active agent with a topical action and at least one polyol, said composition containing no calcium salt, said polyol being present in a quantity which is effective for obtaining a water activity value of said composition of less than or equal to 0.85, said quantity being at least 30% based on the weight of the total composition, and said composition comprising at least one structuring agent selected from the group consisting of acrylic polymers, methacrylic polymers and oils. ### Claim 2 (depends on 1) The composition of claim 1, wherein said polyol is present in a quantity which is effective for obtaining a water activity value of said composition of less than or equal to 0.70. ### Claim 3 (depends on 1) The composition of claim 1, wherein said structuring agent is a polymer and said polymer is selected from the group consisting of acrylic and methacrylic polymers. ### Claim 4 (depends on 1) The composition of claim 1, wherein said polyol is selected from the group consisting of glycerol and glycols. ### Claim 5 (depends on 1) The composition of claim 1, wherein said structuring agent is an oil and said oil is present in a quantity ranging from 5 to 60% by weight, relative to the total weight of the composition. ### Claim 6 (depends on 5) The composition of claim 5, wherein said oil is selected from the group consisting of mineral oils, vegetable oils, animal oils, synthetic oils, silicone oils and fluorinated oils. ### Claim 7 (depends on 1) The composition of claim 1, wherein said water-sensitive active agent with a topical action is selected from the group consisting of enzymes, natural extracts, procyanidol oligomers, vitamins, phosphated and glucosylated vitamins, urea and rutin. ### Claim 8 (depends on 1) The composition of claim 1, wherein said water-sensitive active agent with a topical action is selected from the group consisting of proteases, green teas, ascorbic acid, retinol and esters thereof. ### Claim 9 (depends on 1) The composition of claim 1, wherein said water-sensitive active agent is present in a concentration ranging from 0.001 to 15% by weight, relative to the total weight of the composition. ### Claim 10 (depends on 1) The composition of claim 1, further comprising a magnesium salt or a sodium salt. ### Claim 11 (depends on 1) The composition of claim 1, further comprising at least one lipophilic or hydrophilic adjuvant selected from the group consisting of preservatives, antioxidants, fragrances, fillers, screening agents, sequestering agents, essential oils, coloring compounds, hydrophilic and lipophilic active agents and lipid vesicles. ### Claim 12 (depends on 1) The composition of claim 1 in the form of an emulsion comprising at least one dispersant selected from the group consisting of emulsifiers, vesicles and particles. ### Claim 13 (depends on 1) The composition of claim 1, wherein said polyol is present in a quantity of 40 to 99.99% by weight based on the weight of the total composition. ### Claim 14 (depends on 1) The composition of claim 1, wherein said polyol is present in a quantity of 60 to 80% by weight based on the weight of the total composition. ### Claim 15 (depends on 3) The composition of claim 3 wherein said polyol is totally or partially present as a complex with a polymer containing polymerized monomers selected from the group consisting of acrylic acid, methacrylic acid and esters of acrylic or methacrylic acid with alcohols containing 1 to 10 carbon atoms and 1 to 3 hydroxyl groups. ### Claim 16 (depends on 15) The composition of claim 15, wherein said complex additionally comprises bound water. ### Claim 17 (depends on 16) The composition of claim 16, wherein said polymer, said polyol and said bound water are present in a quantity ranging from 70 to 99.99% by weight, relative to the total weight of the composition. ### Claim 18 (depends on 1) The composition of claim 1 wherein said water-sensitive active agent is a protease. ### Claim 19 (depends on 1) The composition of claim 1 wherein said water-sensitive active agent is a green tea. ### Claim 20 (depends on 15) The composition of claim 15 wherein said water-sensitive active agent is a protease. ### Claim 21 (depends on 5) The composition of claim 5 wherein said water-sensitive active agent is a protease. ### Claim 22 (depends on 21) The composition of claim 21 wherein said oil is a silicone oil. ### Claim 23 (depends on 1) The composition of claim 1 wherein said water-sensitive active agent is an enzyme. ### Claim 24 (depends on 3) The composition of claim 3 wherein said structuring agent is a glyceryl polyacrylate polymer which is complexed with more than 65% of glycerol, propylene glycol or a mixture thereof, and less than 35% by weight of water. ### Claim 25 A composition comprising water, at least one water-sensitive active agent with a topical action and at least one polyol, wherein said polyol is present in a quantity ranging from 30 to 99.99% by weight, relative to the total weight of said composition, and said composition comprises at least one structuring agent selected from the group consisting of acrylic polymers, methacrylic polymers and oils. ### Claim 26 (depends on 1) A method of cleansing and/or protecting the skin and/or keratinous fibers, comprising applying the composition of claim 1 to the skin and/or keratinous fibers.