# US 5,702,929 A · Antifungal agent

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- Number: US 5,702,929 A
- Document ID: US5702929A
- Status: Granted
- Kind: A
- Application number: 08/734,704
- Filed: 1996-10-21
- Granted: 1997-12-30
- Earliest claimed: 1996-10-21
- Assignees: Merck & Co., Inc.
- Inventors: Sandra A. Morris; James E. Curotto; Gerald F. Bills; Sarah J. Dreikorn; Stanley L. Streicher; Deborah L. Zink; John R. Thompson; Angela Basilio; Fernando Pelaez; Maria Teresa Diez; Francisca Vicente
- Web page: https://patentgrep.com/patent/US5702929A

## CPC

- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C12P 17/16: containing two or more hetero rings {(thiamine open chain analogs C12P17/167, i.e. not condensed among themselves or through a common carbocyclic ring system)}
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}

## Abstract

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

## Claims

### Claim 1

A substantially pure compound having the structure: ##STR4##

### Claim 2 (depends on 1)

An antifungal composition comprising an antifungal amount of the compound of claim 1 in admixture with a biologically inert carrier or diluent.

### Claim 3 (depends on 2)

A composition according to claim 2 wherein the carrier is a pharmaceutically acceptable carrier.

### Claim 4 (depends on 1)

A method for controlling fungal growth which comprises administering to the site where growth is to be controlled, an effective amount of the compound of claim 1.

### Claim 5 (depends on 1)

A method for combatting fungal infections in mammals which comprises administering to a region of the animal afflicted with said fungi a therapeutically effective amount of the compound of claim 1.

### Claim 6 (depends on 1)

A process for producing the compound of claim 1 which comprises aerobically cultivating a culture of ATCC 74355 in a nutrient medium containing assimilable sources of carbon and nitrogen and isolating said compound therefrom.

### Claim 7 (depends on 1)

A biologically pure culture of fungus (ATCC 74355) capable of producing the compound of claim 1 in recoverable amounts.